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Y-27632 2HCl

Catalog No. A11001
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ROCK 抑制剂

Y-27632是一种Rho相关的线圈激酶（ROCK）抑制剂，可提高人类胚胎干细胞（hESCs）的克隆效率。比对其他激酶包括PKC，cAMP依赖性蛋白激酶，MLCK和PAK的作用强200多倍。了解更多

Product Citations (27)

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- Sergio Pedraza-Arevalo, .et al. Differentiation of beta-like cells from human induced pluripotent stem cell-derived pancreatic progenitor organoids, STAR Protoc, 2022, Aug 30;3(3):101656 PMID: 36092820
- Ji-Hyun Lee, .et al. p57Kip2 imposes the reserve stem cell state of gastric chief cells, Cell Stem Cell, 2022, May 5; 29(5): 826-839 PMID: 35523142
- Adam Pietrobon, .et al. Renal organoid modeling of tuberous sclerosis complex reveals lesion features arise from diverse developmental processes, Cell Rep, 2022, Jul 5;40(1):111048 PMID: 35793620
- Sarkawt Hamad, .et al. High-efficient serum-free differentiation of endothelial cells from human iPS cells, Stem Cell Res Ther, 2022, Jun 11;13(1):251 PMID: 35690874
- Stasia Krishtul, .et al. Development of a bioactive microencapsulation platform incorporating decellularized extracellular matrix to entrap human induced pluripotent stem cells for versatile biomedical applications, Polym Adv Technol, 2022, 33( 11): 3842-3852
- Peter T Ruane, .et al. Trophectoderm differentiation to invasive syncytiotrophoblast is promoted by endometrial epithelial cells during human embryo implantation, Hum Reprod, 2022, Apr 1;37(4):777-792 PMID: 35079788
- Takayuki Miyoshi, .et al. Successful induction of human chemically induced liver progenitors with small molecules from damaged liver, J Gastroenterol, 2022, Jun;57(6):441-452 PMID: 35294680
- Ana-Maria Cujba, .et al. An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function, Cell Rep, 2022, Mar 1;38(9):110425 PMID: 35235779
- Dan Zhao, .et al. From crypts to enteroids: establishment and characterization of avian intestinal organoids, Poult Sci, 2022, Mar; 101(3): 101642 PMID: 35016046
- Antigoni Gogolou, .et al. Generating Enteric Nervous System Progenitors from Human Pluripotent Stem Cells, Curr Protoc, 2021, Jun;1(6):e137 PMID: 34102038
- Tiago De Oliveira, .et al. Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo, Cancers (Basel), 2021, Mar 2;S2451-9456(21)00095-7 PMID: 33671096
- Denise Muller, .et al. Functional apoptosis profiling identifies MCL-1 and BCL-xL as prognostic markers and therapeutic targets in advanced thymomas and thymic carcinomas, BMC Med, 2021, Nov 16;19(1):300 PMID: 34781947
- Ayumi Horikawa, .et al. A simple method of hiPSCs differentiation into insulin-producing cells is improved with vitamin C and RepSox, PloS one, 2021, Jul 12;16(7):e0254373 PMID: 34252142
- Hayato Mizuta, .et al. Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer, Nat Commun, 2021, Feb 24;12(1):1261 PMID: 33627640
- Scott Bell, .et al. Lesch-Nyhan disease causes impaired energy metabolism and reduced developmental potential in midbrain dopaminergic cells, Stem Cell Reports, 2021, Jul 13;16(7):1749-1762 PMID: 34214487
- Shenyang Li, .et al. Effect of porcine corneal stromal extract on keratocytes from SMILE-derived lenticules, J Cell Mol Med, 2020, Dec 20;25(2):1207-1220 PMID: 33342057
- Takao FUCHIGAMI, .et al. Ameloblastoma cell lines derived from different subtypes demonstrate distinct developmental patterns in a novel animal experimental model, J Appl Oral Sci, 2020, 28: e20190558 PMID: 32348439
- Jing-Yu Lin, .et al. In vitro expansion of pancreatic islet clusters facilitated by hormones and chemicals, Cell Discov, 2020, 6: 20 PMID: 32284878
- Yu Huang, .et al. Development of Bifunctional Three-Dimensional Cysts from Chemically Induced Liver Progenitors, Stem Cells Int, 2019, 2019: 3975689 PMID: 31565060
- XinYan, .et al. Establishment of CSUASOi001-A, a non-integrated induced pluripotent stem cell line from urine-derived cells of a Chinese patient carrying RS1 gene mutation, Stem Cell Res, 2019, May 17 PMID: 31141763
- Daniela F. Duarte Campos, .et al. Corneal bioprinting utilizing collagen?\based bioinks and primary human keratocytes, J Biomed Mater Res A, 2019, April 22 PMID: 31012205
- Scott Bell, .et al. Mutations in ACTL6B Cause Neurodevelopmental Deficits and Epilepsy and Lead to Loss of Dendrites in Human Neurons, Am J Hum Genet, 2019, May 2;104(5):815-834 PMID: 31031012
- Ooi J, .et al. Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects, Cell Rep, 2019, Feb 26;26(9):2494-2508 PMID: 30811996
- Scott Bell, .et al. Disruption of GRIN2B Impairs Differentiation in Human Neurons, Stem Cell Reports, 2018, Jul 10; 11(1):183-196 PMID: 29937144
- Christina Zarouchlioti, .et al. Antisense Therapy for a Common Corneal Dystrophy Ameliorates TCF4 Repeat Expansion-Mediated Toxicity, Am J Hum Genet, 2018, Apr 5; 102(4): 528-539 PMID: 29526280
- Ai Takemoto, .et al. A critical role of platelet TGF-β release in podoplanin-mediated tumour invasion and metastasis, Sci Rep, 2017, 7: 42186 PMID: 28176852
- Scott Bell, .et al. A Rapid Pipeline to Model Rare Neurodevelopmental Disorders with Simultaneous CRISPR/Cas9 Gene Editing, Stem Cells Transl Med, 2017, Mar; 6(3): 886-896 PMID: 28170165
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SLx-2119 (KD025)

Catalog No. A15239
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ROCK2 抑制剂

SLx-2119 (KD025)是ROCK2的小分子和选择性抑制剂，IC50为105 nM。在ROCK1上的选择性> 200倍（IC50 = 24 uM）。了解更多

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RKI-1447

Catalog No. A13067
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ROCK1/ROCK2 抑制剂

RKI-1447是Rho相关ROCK激酶的有效抑制剂，在乳腺癌中具有抗侵袭和抗肿瘤活性。了解更多

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Ripasudil

Catalog No. A15888
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ROCK inhibitor

Ripasudil (K-115) is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension. 了解更多

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GSK429286A

Catalog No. A10441
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ROCK 抑制剂

GSK429286A是含有蛋白激酶(ROCK)的Rho相关卷曲螺旋的细胞渗透性选择性小分子抑制剂。了解更多

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Fasudil HCl (HA-1077)

Catalog No. A10381
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ROCK 抑制剂

Fasudil HCl (HA-1077)是一种环状核苷酸依赖性蛋白激酶抑制剂和Rho相关激酶抑制剂（IC50 = 10.7μM）。了解更多

Product Citations (8)

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- Chengyu Xiang, .et al. Fasudil Ameliorates Osteoporosis Following Myocardial Infarction by Regulating Cardiac Calcitonin Secretion, J Cardiovasc Transl Res, 2022, May 12 PMID: 35551627
- Yeonmi Lee, .et al. Haploidy in somatic cells is induced by mature oocytes in mice, Commun Biol, 2022, Jan 25;5(1):95 PMID: 35079104
- Jiwan Choi, .et al. Efficient hepatic differentiation and regeneration potential under xeno-free conditions using mass-producible amnion-derived mesenchymal stem cells, Stem Cell Res Ther, 2021, Nov 12;12(1):569
- Jee Myung Yang, .et al. Long-term effects of human induced pluripotent stem cell-derived retinal cell transplantation in Pde6b knockout rats, Exp Mol Med, 2021, Apr;53(4):631-642 PMID: 33828232
- Jooyoung Lee, .et al. Hepatogenic Potential and Liver Regeneration Effect of Human Liver-derived Mesenchymal-Like Stem Cells, Cells, 2020, Jun; 9(6): 1521 PMID: 32580448
- Kumar M, .et al. Fasudil hydrochloride ameliorates memory deficits in rat model of streptozotocin-induced Alzheimer's disease: Involvement of PI3-kinase, eNOS and NFκB, Behav Brain Res, 2018, Oct 1;351:4-16 PMID: 29807069
- Wei J, .et al. Inhibition of RHO Kinase by Fasudil Attenuates Ischemic Lung Injury After Cardiac Arrest in Rats, Shock, 2018, Dec;50(6):706-713 PMID: 29283979
- Hofni A, .et al. Fasudil ameliorates endothelial dysfunction in streptozotocin-induced diabetic rats: a possible role of Rho kinase, Naunyn Schmiedebergs Arch Pharmacol, 2017, Aug;390(8):801-811 PMID: 28493050
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AZD5363

Catalog No. A11759
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AKT 抑制剂

AZD5363是有效的AKT抑制剂，在体内具有药效学活性，有潜力作为单一疗法或联合用药来治疗一系列实体瘤和血液肿瘤。了解更多

Product Citations (3)

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- Giri R. Gnawali, .et al. Synthesis of 2-oxoquinoline derivatives as dual pim and mTORC protein kinase inhibitors, Medicinal Chemistry Research, 2022, 31: 1154-1175
- Jeremiah J Bearss, .et al. EDC3 phosphorylation regulates growth and invasion through controlling P-body formation and dynamics, EMBO Rep, 2021, Apr 7;22(4):e50835 PMID: 33586867
- Jin H. Song, .et al. Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase, Mol Cancer Ther, 2018, Dec;17(12):2710-2721 PMID: 30190422

Adooq Bioscience

使用 'ROCK2' 作为标签的产品

Y-27632 2HCl

SLx-2119 (KD025)

RKI-1447

Ripasudil

GSK429286A

Fasudil HCl (HA-1077)

AZD5363

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