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使用 'STAT3' 作为标签的产品

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Alantolactone

Catalog No. A14810
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Alantolactone是一种天然的桉烷类倍半萜内酯，能诱导activin/SMAD3信号、干扰Cripto-1/activin受体ⅡA型受体的相互作用。了解更多

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Cryptotanshinone

Catalog No. A10244
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Stat3 抑制剂

Cryptotanshinone是一种STAT3抑制剂，在DU145细胞中能显着阻断STAT3 Tyr705磷酸化，但不能阻断STAT3 Ser727磷酸化，并显着抑制JAK2磷酸化，IC50为?5μM，而不影响上游激酶c的磷酸化。了解更多

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HO-3867

Catalog No. A14264
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STAT3 抑制剂

HO-3867是一种选择性STAT3抑制剂。了解更多

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Napabucasin

Catalog No. A13474
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STAT 抑制剂

Napabucasin是一种口服小分子药物，它可以阻止癌症干细胞（CSC）自我更新，并诱导CSC和非干细胞中的细胞死亡。了解更多

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Nifuroxazide

Catalog No. A16220
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STAT 抑制剂

Nifuroxazide是STAT激活和信号传导活性的抑制剂，是一种口服硝基呋喃抗生素，用于治疗人类和非人类的结肠炎和腹泻。了解更多

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S3I-201 (NSC 74859)

Catalog No. A10817
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Stat3 抑制剂

S3I-201(NSC 74859)是Stat3的新型抑制剂，可在体外抑制Stat3，Stat3复合物的形成以及Stat3-DNA结合活性（IC50 = 86±33 ?M）和Stat3依赖性转录活性。了解更多

Product Citations (4)

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- Bae WJ, .et al. PTPRD-inactivation-induced CXCL8 promotes angiogenesis and metastasis in gastric cancer and is inhibited. J Exp Clin Cancer Res, 2019, 38:484 PMID: 31805999
- Nishimura K, .et al. Effect of erythropoietin production induced by hypoxia on autophagy in HepG2 cells, Biochem Biophys Res Commun, 2018, Jan 1;495(1):1317-1321 PMID: 29191652
- Ethan L. Morgan, .et al. STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle, PLoS Pathog, 2018, Apr; 14(4): e1006975 PMID: 29630659
- Soleimani AH, .et al. Micellar nano-carriers for the delivery of STAT3 dimerization inhibitors to melanoma, Drug Deliv Transl Res, 2017, Aug;7(4):571-581 PMID: 28290050
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SH-4-54

Catalog No. A14249
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Stat 抑制剂

SH-4-54是一种有效的STAT抑制剂，对STAT3和STAT5的KD为300 nM和464 nM。了解更多

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STA-21

Catalog No. A15885
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STAT-3 抑制剂

STA-21是一种有前途的STAT-3抑制剂，可在类风湿关节炎的实验模型中相互调节Th17和Treg细胞，抑制小鼠和人类的破骨细胞生成并减轻自身免疫炎症。了解更多

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Stattic

Catalog No. A12733
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STAT3 抑制剂

Stattic是第一个非肽类STAT3小分子抑制剂，有效抑制STAT3激活和核易位，IC50为5.1 μM，可通过阻断磷酸化和二聚化事件来选择性抑制Stat3转录因子的激活。了解更多

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WP1066

Catalog No. A11795
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JAK 抑制剂

WP1066是一种新型的JAK2抑制剂，可抑制携带JAK2 V617F突变的类人甲状腺细胞增殖并诱导其凋亡。了解更多

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- Simona Moravcova, .et al. The Circadian Rhythms of STAT3 in the Rat Pineal Gland and Its Involvement in Arylalkylamine-N-Acetyltransferase Regulation, Life (Basel), 2021, Oct 18;11(10):1105 PMID: 34685476

Adooq Bioscience

使用 'STAT3' 作为标签的产品

Alantolactone

Cryptotanshinone

HO-3867

Napabucasin

Nifuroxazide

S3I-201 (NSC 74859)

SH-4-54

STA-21

Stattic

WP1066

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