使用 'Topoisomerase I' 作为标签的产品
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DNA topoisomerase I 抑制剂
Topotecan HCl (Hycamtin)是一种化学治疗剂，是拓扑异构酶抑制剂。
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DNA topoisomerase 抑制剂
SN 38是依立替康(喜树碱的类似物-拓扑异构酶I抑制剂)的活性代谢物。
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- Chen JC, .et al. In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer Cells, Biomolecules, 2019, Sep 9;9(9) PMID: 31505885
- Alibolandi M, .et al. Tetrac-decorated chitosan-coated PLGA nanoparticles as a new platform for targeted delivery of SN38, Artif Cells Nanomed Biotechnol, 2018, May 27:1-12 PMID: 29806500
- Bar-Zeev M, .et al. β-Casein micelles for oral delivery of SN-38 and elacridar to overcome BCRP-mediated multidrug resistance in gastric cancer, Eur J Pharm Biopharm, 2018, Dec;133:240-249 PMID: 30367935
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Topoisomerase 抑制剂
Irinotecan (CPT 11)是喜树碱家族的一种化合物，是参与细胞DNA复制和转录的拓扑异构酶1的抑制剂。
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Topoisomerase I 抑制剂
Irinotecan通过抑制拓扑异构酶防止DNA解链。
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- Gils Jose, .et al. Co-Delivery of CPT-11 and Panobinostat with Anti-GD2 Antibody Conjugated Immunoliposomes for Targeted Combination Chemotherapy, Cancers (Basel), 2020, Oct 31;12(11):E3211 PMID: 33142721
- T Kannathasan, .et al. Chemoresistance-Associated Silencing of miR-4454 Promotes Colorectal Cancer Aggression through the GNL3L and NF-κB Pathway, Cancers (Basel), 2020, May; 12(5): 1231 PMID: 32422901
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Ellagic acid是在多种水果和蔬菜中发现的天然酚类抗氧化剂。鞣花酸的抗增殖和抗氧化特性Ellagic acid促使人们对食用鞣花酸的潜在健康益处进行了初步研究。
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DNA topoisomerase II 抑制剂
Beta-Lapachone是一种选择性的DNA拓扑异构酶I抑制剂，对DNA拓扑异构酶II或连接酶没有抑制活性。
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- Xiaoling Li, .et al. Nanozyme-Augmented Tumor Catalytic Therapy by Self-Supplied H2O2 Generation, ACS Appl. Bio Mater, 2020, 3, 3, 1769-1778
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