使用 'Topoisomerase II' 作为标签的产品
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topoisomerase II 抑制剂
Adriamycin是一种蒽环类抗生素，它通过插入DNA起作用，而最严重的副作用是危及生命的心脏损害。它通常用于治疗多种癌症，包括血液系统恶性肿瘤，多种类型的癌症和软组织肉瘤。
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- Sanaz Naghibi, .et al. Brush-like Polymer Prodrug with Aggregation-Induced Emission Features for Precise Intracellular Drug Tracking, Biosensors (Basel), 2022, May 29;12(6):373 PMID: 35735521
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Topoisomerase 抑制剂
Amonafide (AS1413)是一种DNA插入剂和拓扑异构酶II抑制剂，是治疗肿瘤疾病的抗肿瘤药物之一。
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- Veronica Rendo, .et al. Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy, Nat Commun, 2020, 11: 1308 PMID: 32161261
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Ellagic acid是在多种水果和蔬菜中发现的天然酚类抗氧化剂。鞣花酸的抗增殖和抗氧化特性Ellagic acid促使人们对食用鞣花酸的潜在健康益处进行了初步研究。
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Topoisomerase II 抑制剂
Etoposide (VP-16)是通过抑制topoisomerase II活性而抑制DNA合成。
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- Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
- Chen JC, .et al. In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer Cells, Biomolecules, 2019, Sep 9;9(9) PMID: 31505885
- Takashi Azuma, .et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
- Calhelha RC, .et al. Mathematical models of cytotoxic effects in endpoint tumor cell line assays: critical assessment of the application of a single parametric value as a standard criterion to quantify the dose-response effects and new unexplored proposal formats, Analyst, 2017, Oct 23;142(21):4124-4141 PMID: 28991301
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Topoisomerase II 抑制剂
Flumequine是一种合成化学抗生素，可在回旋酶/拓扑异构酶水平上影响哺乳动物染色体和DNA的解链。抑制拓扑异构酶II， IC50为15 μM。
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Topoisomerase 抑制剂
Idarubicin HCl是蒽环类抗生素，是一种比柔红霉素具有更高DNA结合能力和更大细胞毒性的抗白血病药物。
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- Wei Y, .et al. SUMO-Targeted DNA Translocase Rrp2 Protects the Genome from Top2-Induced DNA Damage, Mol Cell, 2017, Jun 1;66(5):581-596.e6 PMID: 28552615
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Topoisomerase 抑制剂
Marbofloxacin是有效的第三代氟喹诺酮类抗生素，通过抑制细菌DNA复制起作用。
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Mitoxantrone是一种合成的抗肿瘤药蒽二酮（IC50 = 0.42 mM）。
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Mitoxantrone Dihydrochloride是一种抗病毒，抗菌，抗原生动物，免疫调节和抗肿瘤细胞抑制性蒽醌衍生物。
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Topoisomerase 抑制剂
Moxifloxacin HCl是一种喹诺酮/氟喹诺酮类抗菌剂。
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- Hiroshi Arakawa, .et al. Possible interaction of quinolone antibiotics with peptide transporter 1 in oral absorption of peptide-mimetic drugs, Biopharm Drug Dispos, 2016, Jan;37(1):39-45 PMID: 26590007
- Arisa Higa, .et al. Differing responses of human stem cell-derived cardiomyocytes to arrhythmogenic drugs, determined using impedance measurements, Fundam. Toxicol. Sci, 2016, 3(2): 47-53
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Topoisomerase 抑制剂
Ofloxacin (DL8280)是一种合成的广谱抗菌剂。
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Topoisomerase II 抑制剂
Pirarubicin是蒽环类抗肿瘤阿霉素的类似物。插入DNA中并与Topo II（拓扑异构酶II）相互作用并抑制DNA复制。
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- Krishna K Ramajayam, .et al. Selecting ideal drugs for encapsulation in thermosensitive liposomes and other triggered nanoparticles, Int J Hyperthermia, 2022, 39(1):998-1009 PMID: 35876089
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Teniposide是鬼臼毒素的半合成衍生物，具有抗肿瘤活性。
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Topoisomerase 抑制剂
Voreloxin hydrochloride是一种小分子，是具有抗肿瘤活性的萘啶类似物；Topo II抑制剂。
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