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Tedalinab (GRC-10693)是开发用于治疗骨关节炎和神经性疼痛的药物，它可作为有效的选择性大麻素CB2受体激动剂。与相关的CB1受体相比，它对CB2的选择性为4700x，具有很高的口服生物利用度，并在早期临床试验中显示出令人鼓舞的安全性结果以及有效的镇痛和抗炎作用。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.95 mL | 144.76 mL | 289.52 mL |
| 0.5 mM | 5.79 mL | 28.95 mL | 57.9 mL |
| 1 mM | 2.9 mL | 14.48 mL | 28.95 mL |
| 5 mM | 0.58 mL | 2.9 mL | 5.79 mL |
*The above data is based on the productmolecular weight 345.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A14189 |
|---|---|
| 作用机制 | Agonist (激动剂) |
| M. Wt | 345.4 |
| Formula | C19H21F2N3O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 916591-01-0 |
| Synonyms | GRC-10693 |
| SMILES | CC(C)(C)NC(=O)C1=NN(C2=C1[C@H]3CC[C@@H]2C3)C4=C(C=C(C=C4)F)F |
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