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TGR-1202 hydrochloride是一种口服的下一代PI3Kδ抑制剂，在基于酶和细胞的测定中抑制PI3Kδ活性，IC50和EC50值分别为22.2和24.3 nM。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.45 mL | 82.24 mL | 164.47 mL |
| 0.5 mM | 3.29 mL | 16.45 mL | 32.89 mL |
| 1 mM | 1.64 mL | 8.22 mL | 16.45 mL |
| 5 mM | 0.33 mL | 1.64 mL | 3.29 mL |
*The above data is based on the productmolecular weight 608.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16278 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 608.01 |
| Formula | C31H25ClF3N5O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1532533-78-0 |
| Synonyms | RP5264 hydrochloride, TGR1202 hydrochloride, TGR 1202 hydrochloride, RP-5264 hydrochloride, RP 5264 hydrochloride |
| SMILES | O=C1C(C2=CC=CC(F)=C2)=C([C@@H](N3N=C(C4=CC=C(OC(C)C)C(F)=C4)C5=C(N)N=CN=C53)C)OC6=CC=C(F)C=C16.[H]Cl |
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