Thapsigargin

Name: Thapsigargin
SKU: A14007

目录号: A14007

SERCA ATPase 抑制剂

Thapsigargin Chemical Structure

CAS NO. 67526-95-8

Thapsigargin是在Thapsia garganica的根中发现的一种细胞可渗透的倍半萜烯内酯。它是肿瘤的启动子，可通过抑制肌浆/内质网Ca2+ -ATPase（SERCA，IC50 = 30 nM）诱导细胞内储存的Ca2+释放，而不会水解肌醇磷脂。

库存： Discontinuted

规格	价格
5 mg	￥ 1,050.00
10 mg	￥ 1,750.00
25 mg	￥ 3,500.00

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产品详情

溶解度 *

In vitro	DMSO	93 mg/mL (142.9 mM)
	Water	93 mg/mL (142.9 mM)
	Ethanol	93 mg/mL (142.9 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.37 mL	76.83 mL	153.67 mL
0.5 mM	3.07 mL	15.37 mL	30.73 mL
1 mM	1.54 mL	7.68 mL	15.37 mL
5 mM	0.31 mL	1.54 mL	3.07 mL

*The above data is based on the productmolecular weight 650.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A14007
作用机制	Inhibitor (抑制剂)
M. Wt	650.75
Formula	C34H50O12
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	67526-95-8
SMILES	CCCCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=C\C)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCC)([C@](C(=O)O3)(C)O)O