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Thapsigargin是在Thapsia garganica的根中发现的一种细胞可渗透的倍半萜烯内酯。它是肿瘤的启动子，可通过抑制肌浆/内质网Ca2+ -ATPase（SERCA，IC50 = 30 nM）诱导细胞内储存的Ca2+释放，而不会水解肌醇磷脂。
| In vitro | DMSO | 93 mg/mL (142.9 mM) | |
| Water | 93 mg/mL (142.9 mM) | ||
| Ethanol | 93 mg/mL (142.9 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 15.37 mL | 76.83 mL | 153.67 mL |
| 0.5 mM | 3.07 mL | 15.37 mL | 30.73 mL |
| 1 mM | 1.54 mL | 7.68 mL | 15.37 mL |
| 5 mM | 0.31 mL | 1.54 mL | 3.07 mL |
*The above data is based on the productmolecular weight 650.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A14007 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 650.75 |
| Formula | C34H50O12 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 67526-95-8 |
| SMILES | CCCCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=C\C)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCC)([C@](C(=O)O3)(C)O)O |
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