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Thiostrepton抑制细菌蛋白质合成的抗生素。通过GTPase延长因子G（EF-G），EF-TU（GTP）催化的aa-tRNA传递和起始因子2（IF-2）的活性来抑制mRNA-tRNA易位。抗肿瘤剂；通过下调FOXM1表达来诱导乳腺癌细胞的细胞周期停滞和凋亡。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 6.01 mL | 30.03 mL | 60.06 mL |
| 0.5 mM | 1.2 mL | 6.01 mL | 12.01 mL |
| 1 mM | 0.6 mL | 3 mL | 6.01 mL |
| 5 mM | 0.12 mL | 0.6 mL | 1.2 mL |
*The above data is based on the productmolecular weight 1664.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12890 |
|---|---|
| M. Wt | 1664.89 |
| Formula | C72H85N19O18S5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1393-48-2 |
| Synonyms | a-8506 |
| SMILES | CC[C@H](C)[C@@H]1C(=O)N[C@H](C(=O)NC(=C)C(=O)N[C@H](C(=O)N[C@]23CCC(=N[C@@H]2C4=CSC(=N4)[C@H]([C@H](OC(=O)C5=NC6=C(C=CC([C@@H]6O)N1)C(=C5)[C@H](C)O)C)NC(=O)C7=CSC(=N7)[C@@H](NC(=O)C8CSC(=N8)/C(=C/C)/NC(=O)[C@@H](NC(=O)C9=CSC3=N9)[C@@H](C)O)[C@@](C)([C@@H] |
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