Thrombin

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Melagatran

Catalog No. A19083
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Thrombin inhibitor

Melagatran is a direct and orally active inhibitor of thrombin, without interacting with any other enzymes in the coagulation cascade or fibrinolytic enzymes aside from thrombin. 了解更多

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RWJ-445167

Catalog No. A12154
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dual inhibitor of thrombin and factor Xa

RWJ-445167 (3DP-10017) is a dual inhibitor of thrombin and factor Xa with Ki of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity. 了解更多

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Inogatran

Catalog No. A13356
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synthetic thrombin inhibitor

Inogatran (H-314-27) is a synthetic thrombin inhibitor, developed for the possible treatment and prophylaxis of arterial and venous thrombotic diseases. 了解更多

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Odiparcil

Catalog No. A21584
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indirect thrombin inhibitor

Odiparcil (SB-424323) is indirect thrombin inhibitor that exerts its anticoagulant effect through activation of antithrombin II (heparin cofactor II) . 了解更多

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Thrombin Inhibitor 2

Catalog No. A21814
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thrombin inhibitor

Thrombin Inhibitor 2 is a small molecule direct thrombin inhibitor, extracted from US8541580B2. Thrombin Inhibitor 2 has antithrombotic activity. 了解更多

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BIBR-1048 (Dabigatran etexilate)

Catalog No. A10139
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Thrombin 抑制剂

BIBR-1048 (Dabigatran etexilate)是dabigatran的前体药物，dabigatran是一种有效的、非肽类小分子化合物，可特异地、可逆性地抑制游离的和结合了血凝块的凝血酶。了解更多

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BIBR 953 (Dabigatran, Pradaxa)

Catalog No. A10138
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Thrombin 抑制剂

BIBR 953 (Dabigatran,Pradaxa)是一种高度选择性，可逆且有效的凝血酶抑制剂，可作为前药达比加群酯口服。它在血栓形成的动物模型中显示出抗血栓形成的功效，起效迅速，可预测的药效学反应。了解更多

Product Citations (1)

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- Tanaka M, .et al. Protease-activated receptor-1 negatively regulates proliferation of neural stem/progenitor cells derived from the hippocampal dentate gyrus of the adult mouse, J Pharmacol Sci, 2016, Jul;131(3):162-71 PMID: 27426918
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Argatroban

Catalog No. A11774
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Thrombin 抑制剂

Argatroban是一种抗凝剂，是一种小分子直接凝血酶抑制剂，Ki值范围为5 nM-39 nM。了解更多

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Bivalirudin

Catalog No. A15023
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Reversible thrombin 抑制剂

Bivalirudin 是合成的20个残基的肽，可逆地抑制凝血酶。了解更多

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Dabigatran etexilate mesylate

Catalog No. A15057
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direct thrombin 抑制剂

Dabigatran etexilate mesylate是达比加群的口服活性前药。达比加群是一种可逆的选择性直接凝血酶抑制剂（DTI），Ki值为4.5 nM。了解更多

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Dabigatran ethyl ester

Catalog No. A15058
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thrombin 抑制剂

Dabigatran ethyl ester是一种新兴的口服抗凝剂，是凝血酶活性的直接抑制剂。了解更多

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Ximelagatran

Catalog No. A12509
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Thrombin 抑制剂

Ximelagatran是一种抗凝剂，已被广泛研究作为华法林的替代品，它将克服有问题的饮食，药物相互作用以及与华法林治疗相关的监测问题。了解更多

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PPACK

Catalog No. A16048
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Thrombin 抑制剂

PPACK 是一种有效，选择性和不可逆的凝血酶抑制剂，Ki值为0.24 nM。了解更多

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