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Tigecycline具有抑菌作用，是一种蛋白质合成抑制剂，可与细菌的30S核糖体亚基结合，从而在原核翻译过程中阻止氨酰tRNA进入核糖体的A位点。
| In vitro (25°C) | DMSO | 86 mg/mL (146.85 mM) | |
| Water | 86 mg/mL (146.85 mM) | ||
| Ethanol | Insoluble | ||
| In vivo | Saline | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.07 mL | 85.37 mL | 170.74 mL |
| 0.5 mM | 3.41 mL | 17.07 mL | 34.15 mL |
| 1 mM | 1.71 mL | 8.54 mL | 17.07 mL |
| 5 mM | 0.34 mL | 1.71 mL | 3.41 mL |
*The above data is based on the productmolecular weight 585.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10933 |
|---|---|
| M. Wt | 585.7 |
| Formula | C29H39N5O8 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 220620-09-7 |
| Synonyms | Tygacil, GAR-936, WAY-GAR-936, TBG-MINO |
| SMILES | CC(C)(C)NCC(=O)NC1=C(C2=C(C[C@H]3C[C@H]4[C@@H](C(=O)C(=C([C@]4(C(=O)C3=C2O)O)O)C(=O)N)N(C)C)C(=C1)N(C)C)O |
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