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Tirabrutinib (ONO-4059) hydrochloride is a selective and novel inhibitor of BTK with IC50 2.2 nm, Tirabrutinib binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.37 mL | 101.85 mL | 203.69 mL |
| 0.5 mM | 4.07 mL | 20.37 mL | 40.74 mL |
| 1 mM | 2.04 mL | 10.18 mL | 20.37 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.07 mL |
*The above data is based on the productmolecular weight 490.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A22375 |
|---|---|
| M. Wt | 490.94 |
| Formula | C25H23ClN6O3 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 2 years |
| CAS No. | 1439901-97-9 |
| Synonyms | ONO-4059 hydrochloride, GS-4059 hydrochloride |
| SMILES | O=C1N(C2=CC=C(OC3=CC=CC=C3)C=C2)C4=C(N)N=CN=C4N1[C@H]5CN(C(C#CC)=O)CC5.[H]Cl |
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