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TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.86 mL | 149.32 mL | 298.64 mL |
| 0.5 mM | 5.97 mL | 29.86 mL | 59.73 mL |
| 1 mM | 2.99 mL | 14.93 mL | 29.86 mL |
| 5 mM | 0.6 mL | 2.99 mL | 5.97 mL |
*The above data is based on the productmolecular weight 334.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A22382 |
|---|---|
| M. Wt | 334.85 |
| Formula | C14H11ClN4S2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 2 years |
| CAS No. | 864374-00-5 |
| Synonyms | TP 0427736 HCl,TP-0427736 HCl |
| SMILES | CC1=CSC(=N1)C2=C(N=CN2)C3=CC4=C(C=C3)N=CS4 |
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