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TRAM-34是中等电导Ca2+激活的K+通道（KCa3.1）（Kd = 20 nM）的高度选择性阻滞剂。在KV，BKCa，KCa2，Na+，CRAC和Cl-通道上具有200-1500倍的选择性。抑制有丝分裂刺激对淋巴细胞的激活。
靶点信息
| IKCa1 (KCa3.1) | ||||
| 20 nM(Kd) |
| In vitro (25°C) | DMSO | 0.36 mg/mL (1.04 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 2% DMSO+corn oil | 1 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29 mL | 144.99 mL | 289.99 mL |
| 0.5 mM | 5.8 mL | 29 mL | 58 mL |
| 1 mM | 2.9 mL | 14.5 mL | 29 mL |
| 5 mM | 0.58 mL | 2.9 mL | 5.8 mL |
*The above data is based on the productmolecular weight 344.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12783 |
|---|---|
| 作用机制 | Blocker (阻断剂) |
| M. Wt | 344.84 |
| Formula | C22H17ClN2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 289905-88-0 |
| Synonyms | TRAM34, TRAM 34 |
| SMILES | C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CC=N4 |
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