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Trametinib DMSO solvate (GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)) is a potent MEK inhibitor that specifically inhibits MEK1/2, with an IC50 value of about 2 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 14.42 mL | 72.09 mL | 144.19 mL |
| 0.5 mM | 2.88 mL | 14.42 mL | 28.84 mL |
| 1 mM | 1.44 mL | 7.21 mL | 14.42 mL |
| 5 mM | 0.29 mL | 1.44 mL | 2.88 mL |
*The above data is based on the productmolecular weight 693.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21450 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 693.53 |
| Formula | C28H29FIN5O5S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1187431-43-1 |
| Synonyms | GSK-1120212 (DMSO solvate), GSK1120212, GSK 1120212; JTP-74057 (DMSO solvate), JTP74057, JTP 74057 |
| SMILES | CN1C(C(C)=C(N(C(N(C2=O)C3CC3)=O)C4=CC=CC(NC(C)=O)=C4)C2=C1NC5=CC=C(C=C5F)I)=O.CS(C)=O |
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