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TRP Channel

23 个项目

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  1. Pico145
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    Pico145

    Catalog No. A13344
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    TRPC1/4/5 channels inhibitor
    Pico145 is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (?)-englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8. 了解更多
  2. TRPC6-IN-1
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    TRPC6-IN-1

    Catalog No. A12309
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    TRPC6 inhibitor
    TRPC6-IN-1 is a Transient Receptor Potential Canonical 6 Channel (TRPC6) inhibitor, with an EC50 of 4.66 μM. 了解更多
  3. SAR-7334 HCl
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    • 最新产品

    SAR-7334 HCl

    Catalog No. A17237
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    TRPC6 inhibitor
    SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels that opens new opportunities for the investigation of TRPC channel function in vivo. SAR7334 inhibited TRPC6, TRPC3 and TRPC7-mediated Ca(2+) influx into cells with IC50 s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca(2+) entry was not affected. 了解更多
  4. WS 12
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    WS 12

    Catalog No. A17046
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    TRPM8 激动剂
    WS-12是有效的TRPM8激动剂，可作为凉爽剂（EC50 = 193 nM）。 了解更多
  5. WS 3
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    WS 3

    Catalog No. A17047
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    TRPM8 激动剂
    WS 3是TRPM8受体激动剂（EC50 = 3.7 μM）和凉爽剂。 了解更多
  6. PF-4840154
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    PF-4840154

    Catalog No. A13996
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    TrpA1 channel 激动剂
    PF-4840154是TrpA1通道的非亲电参考激动剂。基于TRPA1敲除小鼠在某些临床前发展模型中显示出几乎完全减轻了疼痛行为的事实，因此认为TRPA1通道是有吸引力的疼痛靶标。 了解更多
  7. GsMTx4
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    GsMTx4

    Catalog No. A16103
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    GsMTX4是一种从Grammostola rosea（智利玫瑰）狼蛛毒液分离的34个氨基酸的肽基毒素，属于huwentoxin-1家族。 了解更多
  8. RQ-00203078
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    RQ-00203078

    Catalog No. A15830
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    TRPM8 拮抗剂
    RQ-00203078是一种高度选择性，有效且可口服的TRPM8拮抗剂（大鼠和人类通道的IC50值分别为5.3和8.3 nM），对TRPM8的选择性是TRPV4，TRPV1和TRPA1的> 350倍。 了解更多
  9. ML204
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    ML204

    Catalog No. A15556
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    TRPC4/C5 抑制剂
    ML204是一种新型强效拮抗剂，可选择性调节天然TRPC4/C5离子通道。 了解更多
  10. Cannabichromene
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    Cannabichromene

    Catalog No. A15497
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    TRPA1 activatior/TRPM8 blocker
    Cannabichromene是一种主要的非精神植物大麻素，可抑制内源性大麻素失活并激活瞬时受体电位锚蛋白1（TRPA1）。内源性大麻素和TRPA1均可调节肠胃蠕动。 了解更多
  11. ACA
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    ACA

    Catalog No. A13585
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    ACA是一种通道阻滞剂，作用于多个瞬态受体电位（TRP）通道，包括TRPM2，TRPM8和TRPC6（IC50分别为1.7、3.8和2.3 uM）。 了解更多
  12. TCS 5861528
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    TCS 5861528

    Catalog No. A14126
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    TRPA1 channel blocker
    TCS 5861528是TRPA1通道阻滞剂和AITC和4-HNE诱发的钙流入的拮抗剂。 了解更多
  13. HC-030031
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    HC-030031

    Catalog No. A13278
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    TRPA1 抑制剂
    HC-030031是选择性TRPA1阻滞剂，可拮抗AITC和福尔马林诱导的TRPA1介导的钙内流（IC50分别为6.2和5.3 uM）。 了解更多
  14. Icilin
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    Icilin

    Catalog No. A13560
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    TRPM8 and TRPA1 activator
    Icilin是一种冷却剂，可激活新型的冷受体TRPM8（CMR1）和TRPA1（ANKTM1/TRPN1），它们是TRP离子通道家族的成员。在表达CMR1的HEK 293细胞中感应电流（EC50 = 0.36μM）。 了解更多
  15. Optovin
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    Optovin

    Catalog No. A12932
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    photoactive TRPA1 activator
    Optovin是可逆光敏trpa1活化剂。 了解更多
  16. A 967079
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    A 967079

    Catalog No. A12353
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    TRPA1 channel blocker
    A 967079是选择性TRPA1通道阻滞剂(人和大鼠TRPA1受体的IC50值分别为67和289 nM)。 了解更多
  17. Evodiamine (Isoevodiamine)
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    Evodiamine (Isoevodiamine)

    Catalog No. A10376
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    TRP 激动剂
    Evodiamine (Isoevodiamine)是从Tetradium植物家族中提取的一种化学物质。 它主要起产热和刺激作用。 了解更多
  18. AMG-333
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    AMG-333

    Catalog No. A17182
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    TRPM8 拮抗剂
    AMG-333是有效的选择性TRPM8拮抗剂，IC50为13 nM。 了解更多
  19. AMG2850
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    AMG2850

    Catalog No. A19445
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    TRPM8 antagonist
    AMG2850 is a potent, orally bioavailable and selective transient receptor potential melastatin 8 (TRPM8) antagonist. 了解更多
  20. SAR7334
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    SAR7334

    Catalog No. A20836
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    TRPC6 inhibitor
    SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM. 了解更多
  21. SN 2
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    SN 2

    Catalog No. A20839
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    TRPML3 ion channel activator
    SN 2 is a novel and potent activator of TRPML3 ion channel with EC50 of 1.8??0.13 μM. 了解更多
  22. D-3263
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    D-3263

    Catalog No. A20935
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    TRPM8 agonist
    D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity. 了解更多
  23. Pyr6
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    Pyr6

    Catalog No. A21927
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    TRPC3 inhibitor
    Pyr6 is a selective inhibitor of TRPC3 with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells). 了解更多

23 个项目

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  1. Inhibitor (抑制剂) (7)
  2. Agonist (激动剂) (5)
  3. Antagonist (拮抗剂) (3)
  4. Activator (激活剂) (4)
  5. Blocker (阻断剂) (3)
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