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Membrane Transporters/Ion Channels

产品 51 到 100 共 317个

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  1. Amlodipine besylate (Norvasc)
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    Amlodipine besylate (Norvasc)

    Catalog No. A10069
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    L-type calcium channel blocker
    Amlodipine besylate是一种L型钙通道阻滞剂，具有降压作用。它抑制去极化大鼠主动脉中Ca2 +诱导的收缩（IC50 = 1.9 nM）。 了解更多
  2. Cilnidipine
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    Cilnidipine

    Catalog No. A10215
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    Calcium channel blocker
    Cilnidipine是提供血管平滑肌中L型电压门控钙通道和交感神经末梢N型钙通道的双重阻滞剂。 了解更多
  3. Isradipine
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    Isradipine

    Catalog No. A10487
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    calcium channel blocker
    伊拉地平是二氢吡啶类钙通道阻滞剂。 了解更多
  4. Azelnidipine
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    Azelnidipine

    Catalog No. A11219
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    calcium channel blocker
    Azelnidipine是一种钙阻断剂，可减轻肝纤维化并可能增加抗氧化防御能力。可以减轻肝纤维化并可能增加抗氧化防御能力。 了解更多
  5. Lacidipine
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    Lacidipine

    Catalog No. A11729
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    Lacidipine是一种钙通道阻滞剂。 了解更多
  6. Benidipine hydrochloride
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    Benidipine hydrochloride

    Catalog No. A11730
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    Benidipine hydrochloride是一种长效的T型钙通道阻滞剂，对高血压糖尿病患者的血压和肾功能有影响。 了解更多
  7. Nilvadipine (ARC029)
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    Nilvadipine (ARC029)

    Catalog No. A11731
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    calcium channel blocker
    Nilvadipine (ARC029)是一种钙通道阻滞剂（CCB），用于治疗高血压和慢性主要脑动脉阻塞。 了解更多
  8. Clevidipine
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    Clevidipine

    Catalog No. A11746
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    Calcium channel blocker
    Clevidipine是一种二氢吡啶类钙通道阻滞剂，用于在口服治疗不可行或不理想时降低血压。 了解更多
  9. Diethylstilbestrol
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    Diethylstilbestrol

    Catalog No. A10309
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    Diethylstilbestrol是一种合成的非甾体雌激素，于1938年首次合成。它也被分类为内分泌干扰物。 了解更多
  10. Diltiazem HCl
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    Diltiazem HCl

    Catalog No. A10311
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    Diltiazem HCl是一种非二氢吡啶（非DHP）药物，称为钙通道阻滞剂，用于治疗高血压，心绞痛和某些类型的心律不齐。 了解更多
  11. Manidipine (Manyper)
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    Manidipine (Manyper)

    Catalog No. A10553
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    Manidipine (Manyper)是二氢吡啶化合物和钙通道蛋白抑制剂和拮抗剂。 了解更多
  12. Pinaverium Bromide
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    Pinaverium Bromide

    Catalog No. A12684
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    Pinaverium Bromide是一种痉挛剂，抗胆碱能作用的发生率低。吡那溴铵也是解痉药。 了解更多
  13. Nifedipine
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    Nifedipine

    Catalog No. A10643
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    L-type calcium channel blocker.
    Nifedipine是一种L型钙通道阻滞剂。 了解更多
  14. Nimodipine
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    Nimodipine

    Catalog No. A10645
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    Calcium Channel 抑制剂
    Nimodipine是一种L型Ca2+通道阻滞剂。 了解更多
  15. BAPTA tetrapotassium
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    BAPTA tetrapotassium

    Catalog No. A13989
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    Selective calcium chelator
    BAPTA tetrapotassium是一种选择性钙螯合剂，对Ca2+的亲和力大于Mg2+。 了解更多
  16. BAPTA/AM
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    BAPTA/AM

    Catalog No. A14023
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    Selective calcium chelator
    BAPTA/AM是一种细胞内钙螯合剂，可通过脂氧合酶介导的自由基在小鼠皮层培养物中诱导延迟性坏死。 了解更多
  17. Dantrolene
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    Dantrolene

    Catalog No. A13928
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    Ca2+ release 抑制剂
    Dantrolene是一种肌肉松弛剂，其作用可能是通过消除对ryanodine受体的作用来消除肌肉细胞中的兴奋-收缩偶联。 了解更多
  18. Atagabalin
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    Atagabalin

    Catalog No. A13402
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    Atagabalin与加巴喷丁相关，加巴喷丁同样与α结合。2β钙通道(1和2)。 了解更多
  19. Berbamine
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    Berbamine

    Catalog No. A14794
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    Calcium channel blocker
    Berbamine是钙通道阻滞剂。 了解更多
  20. (S)-Amlodipine
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    (S)-Amlodipine

    Catalog No. A14935
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    Calcium channel blocker
    (S)-Amlodipine是氨氯地平的(S)-对映体，具有活性的二氢吡啶钙通道阻滞剂主要存在于(-)-异构体中。 了解更多
  21. NNC 55-0396
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    NNC 55-0396

    Catalog No. A15188
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    Calcium channel blocker
    NNC 55-0396是Mibefradil衍生物，是一种高度选择性的T型钙通道阻滞剂；分别在INS-1细胞中抑制Cav3.1 T型通道和HVA电流的IC50值为6.8和> 100μM。 了解更多
  22. NP118809
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    NP118809

    Catalog No. A15192
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    N-type calcium channel blocker
    NP118809是有效的N型钙通道阻滞剂（IC50 = 0.11 uM）；对L型钙通道的选择性好。 了解更多
  23. NS6180
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    NS6180

    Catalog No. A12405
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    K(Ca) 3.1 channel blocker
    NS6180是一种新型有效的选择性KCa3.1通道抑制剂（IC50 = 9 nM），可防止T细胞活化和炎症反应。 了解更多
  24. Bay K 8644
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    Bay K 8644

    Catalog No. A15875
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    Calcium Channel Activator
    Bay K 8644是一种有效的L型Ca2+通道选择性激活剂，IC50为17.3 nM。 了解更多
  25. Mibefradil dihydrochloride
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    Mibefradil dihydrochloride

    Catalog No. A12482
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    Calcium channel blocker
    Mibefradil dihydrochloride是钙通道阻滞剂，对T型Ca2+通道具有中等选择性，对T型和L型通道的IC50值分别为2.7 uM和18.6 uM。 了解更多
  26. Dantrolene sodium Hemiheptahydrate
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    Dantrolene sodium Hemiheptahydrate

    Catalog No. A16146
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    Dantrolene sodium是一种骨骼肌松弛剂，其通过干扰肌肉纤维中的激发-收缩偶联起作用。 了解更多
  27. YM-58483
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    YM-58483

    Catalog No. A16346
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    CRAC channel 抑制剂
    YM-58483是CRAC通道和随后的Ca2+信号的第一个选择性抑制剂。 了解更多
  28. Chlorocresol
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    Chlorocresol

    Catalog No. A16444
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    Chlorocresol是ryanodine受体的活化剂。 了解更多
  29. Cinepazide maleate
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    Cinepazide maleate

    Catalog No. A16454
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    Cinepazide maleate是Cinepazide的马来酸盐形式，其为血管扩张剂。 了解更多
  30. Cinnarizine
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    Cinnarizine

    Catalog No. A16455
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    calcium channel blocker
    Cinnarizine是哌嗪的药物衍生物，其特征在于抗组胺药和钙通道阻滞剂。 了解更多
  31. Aranidipine
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    Aranidipine

    Catalog No. A18291
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    Calcium channel antagonist
    Aranidipine (MPC1304) is a Ca2+ channel antagonist with potent and long-lasting antihypertensive effects. 了解更多
  32. ABT-639
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    ABT-639

    Catalog No. A12330
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    T-type Ca2+ channel blocker
    ABT-639 is a novel, peripherally acting, selective T-type Ca2+ channel blocker. 了解更多
  33. Ca2+ channel agonist 1
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    Ca2+ channel agonist 1

    Catalog No. A12186
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    Ca2+ channel agonist/CDK2 inhibitor
    Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2, with EC50s of 14.23 μM and 3.34 μM, respectively, and is used as a potential treatment for motor nerve terminal dysfunction. 了解更多
  34. Barnidipine
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    Barnidipine

    Catalog No. A21940
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    L-type calcium antagonist
    Barnidipine (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors. 了解更多
  35. Dantrolene sodium
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    Dantrolene sodium

    Catalog No. A17644
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    Calcium channel proteins inhibitor
    Dantrolene sodium is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ from the sarcoplasm. Dantrolene sodium is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction. 了解更多
  36. Metaflumizone
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    Metaflumizone

    Catalog No. A18830
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    Sodium channel blocker
    Metaflumizone is a semicarbazone insecticide, acts as a potent sodium channel blocker. 了解更多
  37. Nav1.7-IN-3
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    Nav1.7-IN-3

    Catalog No. A13626
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    voltage-gated sodium channel Nav1.7 inhibitor
    Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration. 了解更多
  38. Funapide
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    Funapide

    Catalog No. A21298
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    Sodium Channel Nav1.7 inhibitor
    Funapide (TV 45070; XEN402) is a potent Sodium Channel Nav1.7 inhibitor. 了解更多
  39. Raxatrigine hydrochloride
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    Raxatrigine hydrochloride

    Catalog No. A21645
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    Nav1.7 sodium channel inhibitor
    Raxatrigine hydrochloride (GSK-1014802 hydrochloride) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor. 了解更多
  40. Riluzole (Rilutek)
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    Riluzole (Rilutek)

    Catalog No. A10795
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    Riluzole (Rilutek)阻断与受损神经元有关的TTX敏感性钠通道，从而减少钙离子的流入并间接防止谷氨酸受体的刺激。 了解更多
  41. A 803467
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    A 803467

    Catalog No. A11234
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    Sodium channel Blocker
    A 803467是NaV1.8通道的选择性阻滞剂（hNaV1.8，hNaV1.3，hNaV1.7，hNaV1.5和hNaV1.2通道的IC50值分别为8、2450、6740、7340和7380 nM）。 了解更多
  42. Lacosamide
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    Lacosamide

    Catalog No. A10510
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    Lacosamide是一种用于辅助治疗部分发作性癫痫发作和糖尿病神经性疼痛的药物。 了解更多
  43. Amiloride HCl
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    Amiloride HCl

    Catalog No. A10064
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    Na+ channel blocker
    Amiloride HCl是一种Na+通道阻滞剂，还抑制TRPP3通道和Na+/H+交换剂（NHE）。 了解更多
  44. Bupivacaine HCl
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    Bupivacaine HCl

    Catalog No. A10168
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    Bupivacaine HCl与化学相关的局部麻醉药相比，Bupivacaine HCl是一种更有效的cAMP抑制剂，较不易产生心血管毒性。 了解更多
  45. PF-04971729
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    PF-04971729

    Catalog No. A11102
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    SGLT2 抑制剂
    PF-04971729是钠依赖性葡萄糖共转运蛋白2的有效和选择性抑制剂。 了解更多
  46. Orphenadrine citrate
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    Orphenadrine citrate

    Catalog No. A11712
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    NMDA receptor 拮抗剂
    Orphenadrine柠檬酸盐是NMDA受体拮抗剂，Ki为6.0μM，还是HERG钾离子通道阻断剂。 了解更多
  47. Proparacaine HCl
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    Proparacaine HCl

    Catalog No. A11715
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    Voltage-gated sodium channels 拮抗剂
    Proparacaine HCl是一种电压门控钠通道拮抗剂，ED50为3.4 mM。 了解更多
  48. Amiloride hydrochloride dihydrate
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    Amiloride hydrochloride dihydrate

    Catalog No. A11728
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    Amiloride hydrochloride dihydrate是一种强效上皮钠通道阻滞剂和选择性低阈值(t型)钙通道蛋白抑制剂(kd=30μm)。 了解更多
  49. Ibutilide fumarate
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    Ibutilide fumarate

    Catalog No. A11750
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    Ibutilide fumarate是一种III类抗心律失常药，用于房颤的急性心脏转换和近期发作的心房扑动转为窦性心律。它通过诱导缓慢的内向钠电流发挥抗心律失常作用，延长心肌细胞的动作电位和不应期(生理学)。 了解更多
  50. Carbamazepine
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    Carbamazepine

    Catalog No. A10179
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    Carbamazepine是一种抗惊厥和稳定情绪的药物，主要用于治疗癫痫和双相情感障碍以及三叉神经痛。 了解更多

产品 51 到 100 共 317个

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分类
  1. ATPase (22)
  2. CFTR (16)
  3. Calcium Channels (47)
  4. Sodium Channels (44)
  5. Potassium Channels (38)
  6. Chloride Channels (7)
  7. SGLT (15)
  8. Monocarboxylate transporters (MCT) (8)
  9. AMPA receptor (33)
  10. P-gp (19)
  11. CRM1 (6)
  12. TRP Channel (23)
  13. TRPV (15)
  14. Glutamate (EAAT) Transporters (1)
  15. Serotonin Transporter (3)
  16. Proton Pump (7)
  17. OCT (4)
  18. NCX (5)
  19. BCRP (6)
  20. MRP (1)
  21. Na+/H+ Exchanger (4)
  22. Monoamine Transporter (3)
作用机制
  1. Inhibitor (抑制剂) (122)
  2. Agonist (激动剂) (12)
  3. Antagonist (拮抗剂) (36)
  4. Activator (激活剂) (22)
  5. Modulator (调节剂) (15)
  6. Blocker (阻断剂) (47)
  7. Inducer (诱导剂) (3)
  8. Potentiator (增强剂) (5)
靶点
  1. DNMT (1)
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