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Membrane Transporters/Ion Channels

产品 51 到 100 共 317个

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  1. ACA
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    ACA

    Catalog No. A13585
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    ACA是一种通道阻滞剂，作用于多个瞬态受体电位（TRP）通道，包括TRPM2，TRPM8和TRPC6（IC50分别为1.7、3.8和2.3 uM）。 了解更多
  2. Cannabichromene
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    Cannabichromene

    Catalog No. A15497
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    TRPA1 activatior/TRPM8 blocker
    Cannabichromene是一种主要的非精神植物大麻素，可抑制内源性大麻素失活并激活瞬时受体电位锚蛋白1（TRPA1）。内源性大麻素和TRPA1均可调节肠胃蠕动。 了解更多
  3. ML204
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    ML204

    Catalog No. A15556
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    TRPC4/C5 抑制剂
    ML204是一种新型强效拮抗剂，可选择性调节天然TRPC4/C5离子通道。 了解更多
  4. RQ-00203078
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    RQ-00203078

    Catalog No. A15830
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    TRPM8 拮抗剂
    RQ-00203078是一种高度选择性，有效且可口服的TRPM8拮抗剂（大鼠和人类通道的IC50值分别为5.3和8.3 nM），对TRPM8的选择性是TRPV4，TRPV1和TRPA1的> 350倍。 了解更多
  5. GsMTx4
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    GsMTx4

    Catalog No. A16103
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    GsMTX4是一种从Grammostola rosea（智利玫瑰）狼蛛毒液分离的34个氨基酸的肽基毒素，属于huwentoxin-1家族。 了解更多
  6. PF-4840154
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    PF-4840154

    Catalog No. A13996
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    TrpA1 channel 激动剂
    PF-4840154是TrpA1通道的非亲电参考激动剂。基于TRPA1敲除小鼠在某些临床前发展模型中显示出几乎完全减轻了疼痛行为的事实，因此认为TRPA1通道是有吸引力的疼痛靶标。 了解更多
  7. WS 3
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    WS 3

    Catalog No. A17047
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    TRPM8 激动剂
    WS 3是TRPM8受体激动剂（EC50 = 3.7 μM）和凉爽剂。 了解更多
  8. WS 12
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    WS 12

    Catalog No. A17046
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    TRPM8 激动剂
    WS-12是有效的TRPM8激动剂，可作为凉爽剂（EC50 = 193 nM）。 了解更多
  9. SAR-7334 HCl
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    • 最新产品

    SAR-7334 HCl

    Catalog No. A17237
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    TRPC6 inhibitor
    SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels that opens new opportunities for the investigation of TRPC channel function in vivo. SAR7334 inhibited TRPC6, TRPC3 and TRPC7-mediated Ca(2+) influx into cells with IC50 s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca(2+) entry was not affected. 了解更多
  10. TRPC6-IN-1
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    TRPC6-IN-1

    Catalog No. A12309
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    TRPC6 inhibitor
    TRPC6-IN-1 is a Transient Receptor Potential Canonical 6 Channel (TRPC6) inhibitor, with an EC50 of 4.66 μM. 了解更多
  11. Pico145
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    Pico145

    Catalog No. A13344
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    TRPC1/4/5 channels inhibitor
    Pico145 is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (?)-englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8. 了解更多
  12. AMG-333
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    AMG-333

    Catalog No. A17182
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    TRPM8 拮抗剂
    AMG-333是有效的选择性TRPM8拮抗剂，IC50为13 nM。 了解更多
  13. AMG2850
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    AMG2850

    Catalog No. A19445
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    TRPM8 antagonist
    AMG2850 is a potent, orally bioavailable and selective transient receptor potential melastatin 8 (TRPM8) antagonist. 了解更多
  14. SAR7334
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    SAR7334

    Catalog No. A20836
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    TRPC6 inhibitor
    SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM. 了解更多
  15. SN 2
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    SN 2

    Catalog No. A20839
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    TRPML3 ion channel activator
    SN 2 is a novel and potent activator of TRPML3 ion channel with EC50 of 1.8??0.13 μM. 了解更多
  16. D-3263
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    D-3263

    Catalog No. A20935
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    TRPM8 agonist
    D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity. 了解更多
  17. Pyr6
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    Pyr6

    Catalog No. A21927
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    TRPC3 inhibitor
    Pyr6 is a selective inhibitor of TRPC3 with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells). 了解更多
  18. KPT185
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    KPT185

    Catalog No. A12975
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    CRM1 抑制剂
    KPT185是选择性CRM1抑制剂。KPT-185以100 nM至500 nM的IC50显着抑制白血病细胞增殖，并诱导AML细胞系和原发性AML原始细胞的细胞周期停滞和凋亡。 了解更多
  19. Selinexor (KPT-330)
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    Selinexor (KPT-330)

    Catalog No. A12582
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    CRM1 抑制剂
    CRM1（XPO1）介导的核输出的KPT-330抑制剂在T细胞急性淋巴细胞白血病和急性骨髓性白血病的临床前模型中具有选择性的抗白血病活性。 了解更多
  20. Piperlongumine
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    Piperlongumine

    Catalog No. A14124
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    TrxR1/CRM1 抑制剂
    Piperlongumine，存在于胡椒科植物荜茇中的一种天然生物碱，能够增加reactive oxygen species (ROS)水平，并选择性杀死癌细胞。它还是TrxR1的直接抑制剂，对胃癌具有抑制活性；一种新型的CRM1抑制剂；在人类乳腺癌细胞中可抑制PI3K/Akt/mTOR。 了解更多
  21. KPT276
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    KPT276

    Catalog No. A16341
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    SINE/CRM1 抑制剂
    KPT276是KPT-185的类似物，是核出口（SINE）和CRM1的选择性抑制剂。 了解更多
  22. Eltanexor Z-isomer
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    Eltanexor Z-isomer

    Catalog No. A21786
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    CRM1 inhibitor
    Eltanexor Z-isomer (KPT-8602 Z-isomer) is the less active isomer of KPT-8602. KPT-8602 is a potent CRM1 inhibitor. 了解更多
  23. Leptomycin B
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    Leptomycin B

    Catalog No. A20985
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    nuclear export receptor CRM1 inhibitor
    Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle. 了解更多
  24. LY335979 (Zosuquidar 3HCl)
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    LY335979 (Zosuquidar 3HCl)

    Catalog No. A10549
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    P-gp modulator
    LY335979 (Zosuquidar trihydrochloride)是一种强效高选择性P-gp抑制剂。 了解更多
  25. PSC-833 (Valspodar)
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    PSC-833 (Valspodar)

    Catalog No. A11080
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    MDR1/P-gp 抑制剂
    PSC-833 (Valspodar)是一种P-糖蛋白（P-gp）调节剂，可抑制P-gp介导的多药耐药性（MDR）。 了解更多
  26. Elacridar (GF120918)
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    Elacridar (GF120918)

    Catalog No. A12324
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    P-gp & BCRP 抑制剂
    Elacridar (GF120918)是一种原型BCRP抑制剂，可抑制Bcrp1介导的转运。 了解更多
  27. Tariquidar (XR9576)
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    Tariquidar (XR9576)

    Catalog No. A11584
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    P-gp 抑制剂
    Tariquidar (XR9576)是一种P-糖蛋白药物外排泵抑制剂。 了解更多
  28. Selamectin
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    Selamectin

    Catalog No. A12363
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    Selamectin是一种局部寄生虫药和抗蠕虫药，用于狗和猫，以治疗和预防犬中的心丝虫，跳蚤，耳螨，螨和某些种类的壁虱感染，并预防心丝虫，跳蚤，耳螨，钩虫和round虫 在猫中。 了解更多
  29. Cynarin
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    Cynarin

    Catalog No. A12004
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    Cynarin是朝鲜蓟中的一种酚类化合物。它具有抗氧化剂和胆汁特性。它是一种潜在的免疫抑制剂。 了解更多
  30. XR9576
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    XR9576

    Catalog No. A13961
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    P-glycoprotein 抑制剂
    XR9576是一种 P-glycoprotein (P-gp) 抑制剂，Kd值为5.1 nM。正在研究中作为抗癌多药耐药性的佐剂。 了解更多
  31. ONT-093
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    ONT-093

    Catalog No. A13531
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    P-gp 抑制剂
    ONT-093是口服可生物利用的P-糖蛋白泵抑制剂，可潜在逆转接受癌症化学疗法的患者的多药耐药性。 了解更多
  32. Laniquidar
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    Laniquidar

    Catalog No. A13532
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    P-gp 抑制剂
    Laniquidar是第三代P-gp抑制剂，已在临床试验中用于调节多药耐药转运蛋白。 了解更多
  33. Biricodar dicitrate (VX-710 dicitrate)
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    Biricodar dicitrate (VX-710 dicitrate)

    Catalog No. A13533
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    P-gp modulator
    Biricodar dicitrate (VX-710 dicitrate)是P-糖蛋白和MRP-1的调节剂；在多药耐药细胞中显示出有效的化学增敏活性。 了解更多
  34. MC 70 HCl
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    MC 70 HCl

    Catalog No. A16080
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    P-gp 抑制剂
    MC 70 HCl是有效的P-gp抑制剂（EC50 = 0.69 uM）。 了解更多
  35. KS-176
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    KS-176

    Catalog No. A16195
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    BCRP 抑制剂
    KS-176是乳腺癌抗性蛋白（BCRP）多药转运蛋白的有效和选择性抑制剂（在Pheo A和Hoechst 33342分析中，IC50值分别为0.59和1.39 uM）。 了解更多
  36. FD 12-9
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    FD 12-9

    Catalog No. A18393
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    P-gp/BCRP dual 抑制剂
    FD 12-9 is a flavonoid dimer, acts as a dual inhibitor of P-gp and BCRP, with EC50s of 285 nM and 0.9 nM, respectively. Anti-glioblastoma activity. 了解更多
  37. Biricodar
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    Biricodar

    Catalog No. A21464
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    P-glycoprotein/MRP-1 modulator
    Biricodar (VX-710) is a modulator of P-glycoprotein and MRP-1; shows effective chemosensitizing activity in multidrug resistant cells. 了解更多
  38. Elacridar hydrochloride
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    Elacridar hydrochloride

    Catalog No. A15077
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    P-gp 抑制剂
    Elacridar hydrochloride是一种P-糖蛋白抑制剂，已在体内和体外用作P-糖蛋白（Pgp）的工具抑制剂，以研究转运蛋白在处理各种测试分子中的作用。 了解更多
  39. Zosuquidar
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    Zosuquidar

    Catalog No. A15289
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    P-gp 抑制剂
    Zosuquidar是P-糖蛋白介导的多药耐药性的有效调节剂，Ki为60 nM。 了解更多
  40. TTT-28
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    TTT-28

    Catalog No. A13033
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    ABCB1 (P-gp/MDR1) inhibitor
    TTT-28 is a synthesized thiazole-valine peptidomimetic, a novel selective inhibitor of ABCB1 (P-gp/MDR1) with high efficacy and low toxicity. 了解更多
  41. Norverapamil hydrochloride
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    Norverapamil hydrochloride

    Catalog No. A12249
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    P-gp inhibitor
    Norverapamil hydrochloride ((??)-Norverapamil hydrochloride), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor. 了解更多
  42. P-gp inhibitor 1
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    P-gp inhibitor 1

    Catalog No. A13384
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    P-gp inhibitor
    P-gp inhibitor 1 is a novel inhibitor reversing P-glycoprotein-mediated multidrug resistance. 了解更多
  43. Aniracetam
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    Aniracetam

    Catalog No. A10078
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    AMPA Receptor 抑制剂
    Aniracetam是一种安非他命，属于消旋体化学类别的促智药，据称比吡乙酰胺更有效。 了解更多
  44. Ampalex (CX-516)
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    Ampalex (CX-516)

    Catalog No. A12349
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    Ampalex (CX-516)是ampakine和nootropic，充当ampa受体阳性变构调节剂。 了解更多
  45. GYKI-52466 dihydrochloride
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    GYKI-52466 dihydrochloride

    Catalog No. A10444
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    AMPA and Kainate 拮抗剂
    GYKI-52466 dihydrochloride是选择性非竞争性AMPA受体拮抗剂(对于AMPA、红藻氨酸和AMPA诱导的反应，IC50值分别为10-20、~ 450和> > 50 μM)。 了解更多
  46. LY404187
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    LY404187

    Catalog No. A12424
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    LY404187是AMPA受体的选择性，有效和中枢活性的正构构调节剂。 了解更多
  47. LY450108
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    LY450108

    Catalog No. A12425
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    LY450108是一种α-氨基-3-羟基-5-甲基-4-异恶唑-丙酸（AMPA）受体增强剂。 了解更多
  48. NBQX
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    NBQX

    Catalog No. A13109
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    AMPA Receptor 拮抗剂
    NBQX是一种有效，选择性和竞争性的AMPA受体拮抗剂。 了解更多
  49. DNQX
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    DNQX

    Catalog No. A13882
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    NMDA receptor 拮抗剂
    DNQX是一种非N-甲基-D-天冬氨酸（非NMDA）受体复合物拮抗剂。 了解更多
  50. IEM 1754 Dihydrobromide
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    IEM 1754 Dihydrobromide

    Catalog No. A14010
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    AMPA Receptor Blocker
    IEM 1754 Dihydrobromide是AMPA受体的电压依赖性明渠阻断剂。 了解更多

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分类
  1. ATPase (22)
  2. CFTR (16)
  3. Calcium Channels (47)
  4. Sodium Channels (44)
  5. Potassium Channels (38)
  6. Chloride Channels (7)
  7. SGLT (15)
  8. Monocarboxylate transporters (MCT) (8)
  9. AMPA receptor (33)
  10. P-gp (19)
  11. CRM1 (6)
  12. TRP Channel (23)
  13. TRPV (15)
  14. Glutamate (EAAT) Transporters (1)
  15. Serotonin Transporter (3)
  16. Proton Pump (7)
  17. OCT (4)
  18. NCX (5)
  19. BCRP (6)
  20. MRP (1)
  21. Na+/H+ Exchanger (4)
  22. Monoamine Transporter (3)
作用机制
  1. Inhibitor (抑制剂) (122)
  2. Agonist (激动剂) (12)
  3. Antagonist (拮抗剂) (36)
  4. Activator (激活剂) (22)
  5. Modulator (调节剂) (15)
  6. Blocker (阻断剂) (47)
  7. Inducer (诱导剂) (3)
  8. Potentiator (增强剂) (5)
靶点
  1. DNMT (1)
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