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Membrane Transporters/Ion Channels

产品 151 到 200 共 317个

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  1. CaCCinh-A01
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    CaCCinh-A01

    Catalog No. A15469
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    CaCCs 抑制剂
    CaCCinh-A01抑制人支气管和肠道细胞中的CaCC电流。还抑制TMEM16A通道（表达TMEM16A的FRT细胞中IC50 = 2.1 uM）。 了解更多
  2. T16Ainh-A01
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    T16Ainh-A01

    Catalog No. A15470
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    TMEM16A 抑制剂
    T16Ainh-A01是一种选择性TMEM16A钙激活的氯离子通道抑制剂，可强烈抑制唾液腺细胞中的氯离子电流。 了解更多
  3. Eact
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    Eact

    Catalog No. A16179
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    CaCC activator
    Eact激活钙激活的氯离子通道（CaCC）TMEM16A CaCC。 了解更多
  4. NPPB
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    NPPB

    Catalog No. A16981
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    chloride channel blocker
    NPPB是一种氯离子通道阻滞剂（IC50 = 80 nM），也被确定为GPR35激动剂。 了解更多
  5. TAK-438 (vonoprazan)
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    TAK-438 (vonoprazan)

    Catalog No. A11239
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    potassium-competitive acid Blocker
    TAK-438 (vonoprazan)是一种新型的钾竞争酸阻滞剂。 了解更多
  6. NS 309
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    NS 309

    Catalog No. A11934
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    KCa3.1 channel activator
    NS 309是小和中电导Ca2+激活的K+通道（KCa2和KCa3.1通道）的正调制器。 了解更多
  7. Glimepiride
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    Glimepiride

    Catalog No. A10430
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    Kir6.2/SUR 抑制剂
    Glimepiride是一种强效Kir6.2/SUR抑制剂，SUR1、SUR2A和SURB的IC50分别为3.0 nM、5.4 nM和7.3 nM，用于治疗2型糖尿病化合物。 了解更多
  8. Retigabine (Ezogabine)
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    Retigabine (Ezogabine)

    Catalog No. A11922
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    Retigabine是一种新型的抗痉挛剂，在大范围的惊厥模型具有活性。其发挥活性的机制主要是开放神经元的KCNQ2-5电压门控钾离子通道。 了解更多
  9. Hydralazine hydrochloride
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    Hydralazine hydrochloride

    Catalog No. A10455
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    Hydralazine hydrochloride是肼屈嗪的盐酸盐(安普索林)，是一种直接作用的平滑肌松弛剂，IC50为1.9 mM。 了解更多
  10. Minoxidil (U-10858)
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    Minoxidil (U-10858)

    Catalog No. A10593
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    Minoxidil (U-10858)是一种选择性的ATP依赖性K+(Kir6)通道激活剂。 了解更多
  11. Nateglinide (Starlix)
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    Nateglinide (Starlix)

    Catalog No. A10629
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    Nateglinide(Starlix)是一种胰岛素促分泌剂，可通过刺激胰腺分泌胰岛素来降低血糖水平。 了解更多
  12. Mitiglinide calcium
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    Mitiglinide calcium

    Catalog No. A11884
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    KATP channel 拮抗剂
    Mitiglinide calcium是一种降血糖药物，通过关闭胰腺β细胞中的ATP敏感K+通道来刺激胰岛素分泌。 了解更多
  13. PAP-1 (5-(4-Phenoxybutoxy)psoralen)
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    PAP-1 (5-(4-Phenoxybutoxy)psoralen)

    Catalog No. A11521
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    Kv1.3 blocker
    PAP-1 (5-(4-Phenoxybutoxy)psoralen) 是一种有效的，选择性的，口服活性的?Kv1.3?阻滞剂 (EC50=2 nM)。PAP-1 以使用依赖性方式阻止 Kv1.3，并通过优先绑定到通道的 C 型灭活状态来起作用。 了解更多
  14. TRAM-34
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    TRAM-34

    Catalog No. A12783
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    Potassium Channel Blocker
    TRAM-34是中等电导Ca2+激活的K+通道（KCa3.1）（Kd = 20 nM）的高度选择性阻滞剂。在KV，BKCa，KCa2，Na+，CRAC和Cl-通道上具有200-1500倍的选择性。抑制有丝分裂刺激对淋巴细胞的激活。 了解更多
  15. E-4031 dihydrochloride
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    E-4031 dihydrochloride

    Catalog No. A12857
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    K+ channel blocker?
    E-4031 dihydrochloride是KV11.1（hERG）通道的选择性阻滞剂；禁止快速延迟整流器K+电流（IKr）。 了解更多
  16. Nicorandil
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    Nicorandil

    Catalog No. A10641
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    Kir6 (KATP) channel opener
    Nicorandil (SG-75) 钾离子通道活化剂。 了解更多
  17. Repaglinide
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    Repaglinide

    Catalog No. A10783
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    Potassium Channel 抑制剂
    Repaglinide是一种有效的短效胰岛素促分泌剂，可通过关闭胰岛β细胞质膜中的ATP敏感性钾（KATP）通道发挥作用。 了解更多
  18. GW 542573X
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    GW 542573X

    Catalog No. A13944
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    KCa2.1 channels activator
    GW 542573X是小电导Ca2+激活的K+通道（KCa2）的激活剂。 了解更多
  19. 20-HETE
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    20-HETE

    Catalog No. A14971
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    20-HETE是在血管平滑肌（VSM）细胞中产生的有效血管收缩剂。 了解更多
  20. Retigabine dihydrochloride
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    Retigabine dihydrochloride

    Catalog No. A15222
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    KCNQ channel opener
    Retigabine dihydrochloride是具有抗惊厥活性的Kv7.2-7.5（KCNQ2-5）神经元钾通道开放剂。 了解更多
  21. KB130015
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    KB130015

    Catalog No. A15493
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    hERG1 potassium channel activator
    KB130015是hERG1钾离子通道的新型激活剂，可在高压下阻断天然和重组hERG1通道，但在低压下激活它们。 了解更多
  22. ICA-110381
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    ICA-110381

    Catalog No. A15503
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    KV7.2/7.3 activator
    ICA-110381是KV7.2/7.3激活剂，EC50为0.38 uM。 了解更多
  23. NS-1643
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    NS-1643

    Catalog No. A15929
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    hERG channel activator
    NS-1643是一种人类以太相关基因（hERG）KV11.1通道激活剂（EC50 = 10.5 uM）。 了解更多
  24. NS1619
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    NS1619

    Catalog No. A15975
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    Potassium channel activator
    NS1619是Bkca开启剂或大电导Ca2+激活的钾（BKCa，KCa1.1）通道激活剂。 了解更多
  25. Doxapram
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    Doxapram

    Catalog No. A15961
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    Doxapram能抑制TASK-1，TASK-3，TASK-1/TASK-3异二聚体通道功能，EC50分别为410 nM，37μM，9μM。Doxapram是一种呼吸刺激剂。静脉注射多沙普兰可刺激潮气量和呼吸频率的增加。 了解更多
  26. K+ Channel inhibitor
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    K+ Channel inhibitor

    Catalog No. A16182
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    K+ Channel 抑制剂
    K+ Channel inhibitor，Kv1.5（IKur）的二氢吡唑并嘧啶抑制剂的合成基础。 了解更多
  27. Cesium chloride
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    Cesium chloride

    Catalog No. A15341
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    Potassium channel blocker
    Cesium chloride是钾通道阻滞剂。抑制起搏器电流（If）和超极化激活的阳离子电流（Ih）。通过灭活GSK-3β来防止血清和钾缺乏的小脑颗粒神经元中caspase-3的激活和神经元凋亡。 了解更多
  28. SKA-31
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    • 最新产品

    SKA-31

    Catalog No. A17117
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    potassium channel activator
    SKA-31是KCa2和KCa3.1钙激活钾通道的激活剂。 了解更多
  29. 4-Aminopyridine
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    4-Aminopyridine

    Catalog No. A17490
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    Potassium channel blocker
    Dalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk. 了解更多
  30. AUT1
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    AUT1

    Catalog No. A18648
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    Kv3 potassium channel modulator
    AUT1 is a Kv3 potassium channel modulator with pEC50s of 5.33 and 5.31 for human recombinant Kv3.1b and Kv3.2a, respectively, exhibits 10-fold lower potency at human recombinant Kv3.3 channel (pEC50, 4.5). 了解更多
  31. ML418
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    ML418

    Catalog No. A18426
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    Kir7.1 potassium channels blocker
    ML418 is a selective, sub-micromolar pore blocker of Kir7.1 potassium channels. The inward rectifier potassium (Kir) channel Kir7.1 (KCNJ13) is a key regulator of melanocortin signaling in the brain, electrolyte homeostasis in the eye, and uterine muscle contractility during pregnancy. 了解更多
  32. Y-26763
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    Y-26763

    Catalog No. A12271
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    K+ (KATP) channel activator
    Y-26763 is a K+ channel opener and active metabolite of Y-27152. Y-26763 is an ATP-sensitive K+ (KATP) channel activator. 了解更多
  33. JNJ 303
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    JNJ 303

    Catalog No. A20952
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    IKs blocker
    JNJ 303 is a potent IKs blocker with an IC50 value of 64 nM. 了解更多
  34. RPR-260243
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    RPR-260243

    Catalog No. A20977
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    HERG activator
    RPR-260243 is a novel activator of HERG; modifies HERG currents inhibited by dofetilide (IC50 = 58 nM); little effect on HERG current amplitude and no significant effects on steady-state activation parameters or on channel inactivation processes. 了解更多
  35. MK-7145
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    MK-7145

    Catalog No. A21030
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    ROMK inhibitor
    MK-7145 is a ROMK inhibitor, with an IC50 of 0.045 μM. 了解更多
  36. Cisapride
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    Cisapride

    Catalog No. A21340
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    hERG potassium channel inhibitor
    Cisapride(R 51619) is a nonselective 5-HT4 receptor agonist, it is also a potent hERG potassium channel inhibitor. 了解更多
  37. VU591
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    VU591

    Catalog No. A21362
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    potassium channel inhibitor
    VU591 is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM. 了解更多
  38. ML277
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    ML277

    Catalog No. A21749
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    KCNQ1 potassium channel activator
    ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM. 了解更多
  39. Riluzole (Rilutek)
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    Riluzole (Rilutek)

    Catalog No. A10795
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    Riluzole (Rilutek)阻断与受损神经元有关的TTX敏感性钠通道，从而减少钙离子的流入并间接防止谷氨酸受体的刺激。 了解更多
  40. A 803467
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    A 803467

    Catalog No. A11234
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    Sodium channel Blocker
    A 803467是NaV1.8通道的选择性阻滞剂（hNaV1.8，hNaV1.3，hNaV1.7，hNaV1.5和hNaV1.2通道的IC50值分别为8、2450、6740、7340和7380 nM）。 了解更多
  41. Lacosamide
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    Lacosamide

    Catalog No. A10510
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    Lacosamide是一种用于辅助治疗部分发作性癫痫发作和糖尿病神经性疼痛的药物。 了解更多
  42. Amiloride HCl
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    Amiloride HCl

    Catalog No. A10064
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    Na+ channel blocker
    Amiloride HCl是一种Na+通道阻滞剂，还抑制TRPP3通道和Na+/H+交换剂（NHE）。 了解更多
  43. Bupivacaine HCl
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    Bupivacaine HCl

    Catalog No. A10168
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    Bupivacaine HCl与化学相关的局部麻醉药相比，Bupivacaine HCl是一种更有效的cAMP抑制剂，较不易产生心血管毒性。 了解更多
  44. PF-04971729
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    PF-04971729

    Catalog No. A11102
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    SGLT2 抑制剂
    PF-04971729是钠依赖性葡萄糖共转运蛋白2的有效和选择性抑制剂。 了解更多
  45. Orphenadrine citrate
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    Orphenadrine citrate

    Catalog No. A11712
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    NMDA receptor 拮抗剂
    Orphenadrine柠檬酸盐是NMDA受体拮抗剂，Ki为6.0μM，还是HERG钾离子通道阻断剂。 了解更多
  46. Proparacaine HCl
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    Proparacaine HCl

    Catalog No. A11715
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    Voltage-gated sodium channels 拮抗剂
    Proparacaine HCl是一种电压门控钠通道拮抗剂，ED50为3.4 mM。 了解更多
  47. Amiloride hydrochloride dihydrate
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    Amiloride hydrochloride dihydrate

    Catalog No. A11728
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    Amiloride hydrochloride dihydrate是一种强效上皮钠通道阻滞剂和选择性低阈值(t型)钙通道蛋白抑制剂(kd=30μm)。 了解更多
  48. Ibutilide fumarate
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    Ibutilide fumarate

    Catalog No. A11750
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    Ibutilide fumarate是一种III类抗心律失常药，用于房颤的急性心脏转换和近期发作的心房扑动转为窦性心律。它通过诱导缓慢的内向钠电流发挥抗心律失常作用，延长心肌细胞的动作电位和不应期(生理学)。 了解更多
  49. Carbamazepine
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    Carbamazepine

    Catalog No. A10179
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    Carbamazepine是一种抗惊厥和稳定情绪的药物，主要用于治疗癫痫和双相情感障碍以及三叉神经痛。 了解更多
  50. Lidocaine (Alphacaine)
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    Lidocaine (Alphacaine)

    Catalog No. A10530
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    Lidocaine (Alphacaine)是一种麻醉剂和Ib类抗心律失常药。在失活状态下阻断电压门控钠通道。 了解更多

产品 151 到 200 共 317个

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购物选项

分类
  1. ATPase (22)
  2. CFTR (16)
  3. Calcium Channels (47)
  4. Sodium Channels (44)
  5. Potassium Channels (38)
  6. Chloride Channels (7)
  7. SGLT (15)
  8. Monocarboxylate transporters (MCT) (8)
  9. AMPA receptor (33)
  10. P-gp (19)
  11. CRM1 (6)
  12. TRP Channel (23)
  13. TRPV (15)
  14. Glutamate (EAAT) Transporters (1)
  15. Serotonin Transporter (3)
  16. Proton Pump (7)
  17. OCT (4)
  18. NCX (5)
  19. BCRP (6)
  20. MRP (1)
  21. Na+/H+ Exchanger (4)
  22. Monoamine Transporter (3)
作用机制
  1. Inhibitor (抑制剂) (122)
  2. Agonist (激动剂) (12)
  3. Antagonist (拮抗剂) (36)
  4. Activator (激活剂) (22)
  5. Modulator (调节剂) (15)
  6. Blocker (阻断剂) (47)
  7. Inducer (诱导剂) (3)
  8. Potentiator (增强剂) (5)
靶点
  1. DNMT (1)
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