Membrane Transporters/Ion Channels
-
L-type Ca2+ channel agonist
(S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel. (S)-(-)-Bay-K-8644 activates Ba2+ currents (IBa) (EC50=32 nM).
了解更多
-
N- and P/Q-type Ca2+ channels agonist
GV-58 is a potent, selective N- and P/Q-type Ca2+ channels agonist with EC50 of 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel; 20-fold less potent CDK inhibitor activity.
了解更多
-
Ca2+ channel agonist/CDK2 inhibitor
Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2, with EC50s of 14.23 μM and 3.34 μM, respectively, and is used as a potential treatment for motor nerve terminal dysfunction.
了解更多
-
AMPAR agonist
(S)-(-)-5-Fluorowillardiine is a potent and specific AMPAR agonist.
了解更多
-
AMPA/kainate receptors agonist
(S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM.
了解更多
-
TRPM8 agonist
D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity.
了解更多
-
TRP 激动剂
Evodiamine (Isoevodiamine)是从Tetradium植物家族中提取的一种化学物质。 它主要起产热和刺激作用。
了解更多
-
TrpA1 channel 激动剂
PF-4840154是TrpA1通道的非亲电参考激动剂。基于TRPA1敲除小鼠在某些临床前发展模型中显示出几乎完全减轻了疼痛行为的事实,因此认为TRPA1通道是有吸引力的疼痛靶标。
了解更多
-
TRPM8 激动剂
WS 3是TRPM8受体激动剂(EC50 = 3.7 μM)和凉爽剂。
了解更多
-
TRPM8 激动剂
WS-12是有效的TRPM8激动剂,可作为凉爽剂(EC50 = 193 nM)。
了解更多
-
vanilloid receptor 激动剂
Resiniferatoxin是从大戟属(Euphorbia)属的一些植物中分离出的辣椒素的天然类似物(货号92350),包括E. resinifera。
了解更多
- Thieu X. Phan, .et al. TRPV1 in arteries enables a rapid myogenic tone, bioRxiv, 2021, February 27
- Thieu X Phan, .et al. TRPV1 expressed throughout the arterial circulation regulates vasoconstriction and blood pressure, J Physiol, 2020, Sep 17 PMID: 32944976
- Thieu X. Phan, .et al. TRPV1 expressed throughout the arterial circulation regulates vasoconstriction, bioRxiv, 2020, February 04
-
TRPV1 agonist
Zucapsaicin, also known as cis-Capsaicin, is a medication used to treat osteoarthritis of the knee and other neuropathic pain. It is applied three times daily for a maximum of three months. It reduces pain, and improves articular functions.
了解更多