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Membrane Transporters/Ion Channels

Membrane Transporters/Ion Channels

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Rostafuroxin (PST-2238)

Catalog No. A13283
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Na+/K+ ATPase modulator

Rostafuroxin (PST-2238)是一种哇巴因抑制剂，可对抗特定形式的高血压。了解更多

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VX-809 (Lumacaftor)

Catalog No. A10986
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CFTR modulator

VX-809 (Lumacaftor)是用于治疗囊性纤维化（CF）的第二种口服研究候选化合物，通过促进突变型CFTR(F508del-CFTR)的成熟，从而纠正囊性纤维症中常见的CFTR突变，在fisher大鼠甲状腺细胞中EC50为0.1 μM。了解更多

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- Kusumika Saha, .et al. Pharmacological chaperone-rescued cystic fibrosis CFTR-F508del mutant overcomes PRAF2-gated access to endoplasmic reticulum exit sites, Cell Mol Life Sci, 2022, Sep 27;79(10):530 PMID: 36167862
- Heledd H Jarosz-Griffiths, .et al. Different CFTR Modulator Combinations Downregulate Inflammation Differently in Cystic Fibrosis, Elife, 2020, Mar 2;9:e54556 PMID: 32118580
- Okiyoneda T, .et al. Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase, Dev Cell, 2018, Mar 26;44(6):694-708.e7 PMID: 29503157
- Junko Kido, .et al. Cystic Fibrosis Transmembrane Conductance Regulator Reduces Microtubule-Dependent Campylobacter jejuni Invasion, Infect Immun, 2017, Oct; 85(10): e00311-17 PMID: 28784926
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Caldaret

Catalog No. A13148
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intracellular Ca2+ handling modulator

Caldaret is an intracellular Ca2+ handling modulator that acts through reverse mode Na+/Ca2+ exchanger inhibition. 了解更多

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Astragaloside A

Catalog No. A11405
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Ca2+ signaling modulator

Astragaloside A是缺氧条件下人脐静脉内皮细胞HIF-1α和通过PI3K/Akt途径血管生成的一种新型调节因子。了解更多

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AUT1

Catalog No. A18648
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Kv3 potassium channel modulator

AUT1 is a Kv3 potassium channel modulator with pEC50s of 5.33 and 5.31 for human recombinant Kv3.1b and Kv3.2a, respectively, exhibits 10-fold lower potency at human recombinant Kv3.3 channel (pEC50, 4.5). 了解更多

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CMPDA

Catalog No. A21909
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AMPA receptors positive allosteric modulator

CMPDA is a positive allosteric modulator of AMPA receptors with EC50s of 45.4 ?? 4.2 nM/63.4 ?? 5.6 nM for GluA2i/GluA2o receptor. 了解更多

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PF-4778574

Catalog No. A21157
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AMPA receptor positive allosteric modulator

PF-4778574 is a potent AMPA receptor positive allosteric modulator (PAM) that has been shown to enhance cognition in animal models. 了解更多

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JNJ-61432059

Catalog No. A20209
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AMPAR negative modulator

JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. 了解更多

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PEPA

Catalog No. A21904
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AMPA receptors allosteric modulator

PEPA is an allosteric modulator of AMPA receptors; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity. 了解更多

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CX546

Catalog No. A21923
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positive AMPAR modulator

CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent. 了解更多

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Farampator

Catalog No. A13798
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AMPA receptor modulator

Farampator是一种AMPA受体正调节剂，它可以改善短期记忆，但会损害情景记忆。了解更多

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Biricodar dicitrate (VX-710 dicitrate)

Catalog No. A13533
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P-gp modulator

Biricodar dicitrate (VX-710 dicitrate)是P-糖蛋白和MRP-1的调节剂；在多药耐药细胞中显示出有效的化学增敏活性。了解更多

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LY335979 (Zosuquidar 3HCl)

Catalog No. A10549
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P-gp modulator

LY335979 (Zosuquidar trihydrochloride)是一种强效高选择性P-gp抑制剂。了解更多

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- Leo Shen, .et al. A forward genetic screen identifies modifiers of rocaglate responsiveness, Sci Rep, 2021, Sep 16;11(1):18516 PMID: 34531456
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Biricodar

Catalog No. A21464
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P-glycoprotein/MRP-1 modulator

Biricodar (VX-710) is a modulator of P-glycoprotein and MRP-1; shows effective chemosensitizing activity in multidrug resistant cells. 了解更多

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MRS1477

Catalog No. A15498
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TRPV1 modulator

MRS1477是TRPV1阳性变构调节剂。了解更多

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