TRPV

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SB-705498

Catalog No. A11143
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TRPV1 拮抗剂

SB-705498是有效，选择性和口服生物利用的TRPV1拮抗剂，抑制TRPV1的Capsaicin，酸和热激活，IC50分别为3 nM， 0.1 nM和6 nM，该作用具有一定的电压依赖性，作用于TRPV1比作用于TRPM8选择性高100倍以上。了解更多

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AMG517

Catalog No. A12727
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TRPV1 拮抗剂

AMG 517是有效的选择性TRPV1拮抗剂。了解更多

Product Citations (2)

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- Jun Hai, .et al. Intragastric administration of AMG517, a TRPV1 antagonist, enhanced activity-dependent energy metabolism via capsaicin-sensitive sensory nerves in mice, Biosci Biotechnol Biochem, 2020, Jul 7;1-7 PMID: 32633621
- Hai J, .et al. Differences in the effects of TRPV1 antagonists on energy metabolism in mice, Biomed Res, 2018, 39(6):279-286 PMID: 30531157
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A-889425

Catalog No. A13497
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TRPV1 receptor 拮抗剂

A-889425是选择性TRPV1受体拮抗剂。A-889425阻断TRPV1通道，IC50为335 nM（大鼠）和34 nM（人）。了解更多

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Linoleyl ethanolamide

Catalog No. A15496
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Linoleyl ethanolamide是一种内源性大麻素，也与TRPV1结合（Ki = 5.60 uM）。了解更多

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MRS1477

Catalog No. A15498
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TRPV1 modulator

MRS1477是TRPV1阳性变构调节剂。了解更多

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Mavatrep

Catalog No. A15778
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TRPV1 拮抗剂

Mavatrep是生物利用的TRPV1拮抗剂（Ki = 6.5 nM），对CYP亚型3A4、1A2和2D6的酶活性（IC50> 25μM）影响很小。了解更多

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SB366791

Catalog No. A15857
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TRPV1 receptor 拮抗剂

SB-366791是新颖，有效且选择性的肉桂酰胺TRPV1拮抗剂。了解更多

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Capsazepine

Catalog No. A21208
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TRPV1 receptor

Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, and an antagonist of TRPV1 receptor with an IC50 of 562 nM. 了解更多

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A-1165442

Catalog No. A21516
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TRPV1 antagonist

A-1165442 is a potent, competitive and orally available TRPV1 antagonist with an IC50 of 9 nM for human TRPV1. 了解更多

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GSK-2193874

Catalog No. A14201
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TRPV4 blocker

GSK2193874被确定为选择性的口服活性TRPV4阻滞剂，可通过重组TRPV4通道和天然内皮TRPV4电流抑制Ca(2+)流入。了解更多

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Resiniferatoxin

Catalog No. A14003
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vanilloid receptor 激动剂

Resiniferatoxin是从大戟属（Euphorbia）属的一些植物中分离出的辣椒素的天然类似物（货号92350），包括E. resinifera。了解更多

Product Citations (3)

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- Thieu X. Phan, .et al. TRPV1 in arteries enables a rapid myogenic tone, bioRxiv, 2021, February 27
- Thieu X Phan, .et al. TRPV1 expressed throughout the arterial circulation regulates vasoconstriction and blood pressure, J Physiol, 2020, Sep 17 PMID: 32944976
- Thieu X. Phan, .et al. TRPV1 expressed throughout the arterial circulation regulates vasoconstriction, bioRxiv, 2020, February 04
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GSK1016790A

Catalog No. A15854
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TRPV4 Activator

GSK1016790A是一种新型有效的TRPV4激活剂（瞬态受体电位香草酸4），在脉络丛上皮细胞中的EC50为34nM。了解更多

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(+)-Camphor

Catalog No. A16423
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(+)-Camphor是蜡状，易燃，白色或透明的固体，具有强烈的香气，通常用于缓解疼痛，减少瘙痒和治疗真菌感染。它可以激活TRPV1和TRPV3。了解更多

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(Z)-Capsaicin

Catalog No. A18179
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TRPV1 agonist

Zucapsaicin, also known as cis-Capsaicin, is a medication used to treat osteoarthritis of the knee and other neuropathic pain. It is applied three times daily for a maximum of three months. It reduces pain, and improves articular functions. 了解更多

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JNJ-17203212

Catalog No. A12766
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TRPV1 antagonist

NJ-17203212 is a novel and selective TRPV1 antagonist, with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1. 了解更多

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