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UCB-9260, an orally active compound, inhibits TNF signaling by stabilising an asymmetric form of the trimer. UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar Kd of 13?nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.61 mL | 118.06 mL | 236.12 mL |
| 0.5 mM | 4.72 mL | 23.61 mL | 47.22 mL |
| 1 mM | 2.36 mL | 11.81 mL | 23.61 mL |
| 5 mM | 0.47 mL | 2.36 mL | 4.72 mL |
*The above data is based on the productmolecular weight 423.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A22416 |
|---|---|
| M. Wt | 423.51 |
| Formula | C26H25N5O |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 2 years |
| CAS No. | 1515888-53-5 |
| Synonyms | UCB9260,UCB 9260 |
| SMILES | OC(C1=CC=NC=C1)C2=NC3=CC=C(C4=CN(C)N=C4)C=C3N2CC5=CC(C)=CC=C5C |
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