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Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.46 mL | 97.31 mL | 194.63 mL |
| 0.5 mM | 3.89 mL | 19.46 mL | 38.93 mL |
| 1 mM | 1.95 mL | 9.73 mL | 19.46 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.89 mL |
*The above data is based on the productmolecular weight 513.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18987 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 513.8 |
| Formula | C19H15ClF7N5O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1387560-01-1 |
| Synonyms | CNP 520, CNP-520 |
| SMILES | O=C(NC1=NC([C@@]2(CO[C@](C)(C(N)=N2)C(F)(F)F)C)=C(C=C1)F)C3=NC=C(C=C3Cl)C(F)(F)F |
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