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UNC 9994 hydrochloride,独特的,β-arrestin偏向的功能选择性多巴胺D2受体(D2R)激动剂(Ki值为30 nM;在ε-arrestin-2募集试验中EC50值为50 nM),在体内具有抗精神病活性。UNC9994在野生型小鼠中显着抑制了PCP诱导的超运动,而在Δr-arrestin-2基因敲除小鼠中这种作用被完全消除。
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 21.84 mL | 109.21 mL | 218.42 mL |
0.5 mM | 4.37 mL | 21.84 mL | 43.68 mL |
1 mM | 2.18 mL | 10.92 mL | 21.84 mL |
5 mM | 0.44 mL | 2.18 mL | 4.37 mL |
*The above data is based on the productmolecular weight 457.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
目录号 | A16087 |
---|---|
作用机制 | Agonist (激动剂) |
M. Wt | 457.84 |
Formula | C21H23Cl3N2OS |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. |
CAS No. | 1354030-51-5 |
Synonyms | UNC9994 hydrochloride |
SMILES | C1CN(CCC1C2=C(C(=CC=C2)Cl)Cl)CCCOC3=CC4=C(C=C3)SC=N4.Cl |
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