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USP7-IN-1是一种新型的USP7选择性可逆抑制剂，IC50为33 uM。 对USP5，USP8，Uch-L1，Uch-L3和胱天蛋白酶的抑制作用很小或没有抑制作用（IC50> 200 uM）；HCT116细胞活力GI50为67 uM。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.48 mL | 117.4 mL | 234.79 mL |
| 0.5 mM | 4.7 mL | 23.48 mL | 46.96 mL |
| 1 mM | 2.35 mL | 11.74 mL | 23.48 mL |
| 5 mM | 0.47 mL | 2.35 mL | 4.7 mL |
*The above data is based on the productmolecular weight 425.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12813 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 425.91 |
| Formula | C23H24ClN3O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1381291-36-6 |
| SMILES | ClC1=CC=C(C(N(CC2(O)CCN(C(CCC3=CC=CC=C3)=O)CC2)C=N4)=O)C4=C1 |
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