VDA

Inhibitory Selectivity

Catalog No.	Inhibitor Name	VDA	Other
A10324	DMXAA (ASA404, Vadimezan)	**
A10654	NPI-2358 (Plinabulin)	***
A12658	Verteporfin		YAP/TEAD interaction

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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DMXAA (ASA404, Vadimezan)

Catalog No. A10324
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Vascular Disrupting Agent (VDA)

DMXAA (ASA404,Vadimezan)是一种肿瘤血管破坏剂（tumor-VDA），也是一种DT-diaphorase的竞争性抑制剂。了解更多

Product Citations (3)

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- Zhang X, .et al. Discovery and Mechanistic Study of a Novel Human-Stimulator-of-Interferon-Genes Agonist, ACS Infect Dis, 2019, May 14 PMID: 31060350
- Bowei Liu, .et al. A cell-based high throughput screening assay for the discovery of cGAS-STING pathway agonists, Antiviral Res, 2017, Nov; 147: 37-46 PMID: 28982551
- Fang Guo, .et al. Activation of Stimulator of Interferon Genes in Hepatocytes Suppresses the Replication of Hepatitis B Virus, Antimicrob Agents Chemother, 2017, Oct; 61(10): e00771-17 PMID: 28717041
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Verteporfin

Catalog No. A12658
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YAP 抑制剂

Verteporfin是抑制TEAD-YAP缔合和YAP诱导的肝过度生长的小分子。它也是一种有效的第二代光敏剂，衍生自卟啉。了解更多

Product Citations (3)

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- Po-Ju Lee, .et al. Epstein-Barr viral product-containing exosomes promote fibrosis and nasopharyngeal carcinoma progression through activation of YAP1/FAPα signaling in fibroblasts, J Exp Clin Cancer Res, 2022, Aug 20;41(1):254 PMID: 35986369
- Wang Y, .et al. Verteporfin inhibits lipopolysaccharide-induced inflammation by multiple functions in RAW 264.7 cells, Toxicol Appl Pharmacol, 2019, 2019 Dec 5;387:114852 PMID: 31812773
- Abe T, .et al. Role of YAP Activation in Nuclear Receptor CAR-Mediated Proliferation of Mouse Hepatocytes, Toxicol Sci, 2018, Oct 1;165(2):408-419 PMID: 29893953
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NPI-2358 (Plinabulin)

Catalog No. A10654
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Microtubule 抑制剂

NPI-2358 (Plinabulin)是NPI-2350的合成类似物，NPI-2350是从曲霉属（Aspergillus sp.）分离的天然产物，可解聚A549人肺癌细胞中的微管。了解更多

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Oxi 4503

Catalog No. A14352
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VDA

Oxi4503是一种新型血管靶向剂，与康普他汀A-4磷酸酯相比，对血流和抗肿瘤活性有影响。了解更多

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