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WK23是基于四个芳香族基团的抑制剂，能够有效填充MDM2/MDMX的结合口袋，其对MDM2/MDMX的中位抑制浓度（IC50）值分别为1.17和36 uM。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.63 mL | 108.15 mL | 216.3 mL |
| 0.5 mM | 4.33 mL | 21.63 mL | 43.26 mL |
| 1 mM | 2.16 mL | 10.81 mL | 21.63 mL |
| 5 mM | 0.43 mL | 2.16 mL | 4.33 mL |
*The above data is based on the productmolecular weight 462.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A14051 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 462.33 |
| Formula | C25H17Cl2N3O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| Synonyms | WK-23, WK 23 |
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