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Stem Cells / Wnt /
Wnt

Wnt

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Longdaysin

Catalog No. A21022
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Wnt/??-catenin signaling inhibitor

Longdaysin is a inhibitor of the Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling. 了解更多

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pyrvinium

Catalog No. A17784
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Wnt 抑制剂

Pyrvinium pamoate is an FDA-approved antihelmintic drug that inhibits WNT pathway signaling. 了解更多

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IWP-4

Catalog No. A17004
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Wnt/β-catenin signaling 抑制剂

IWP-4是Wnt /β-catenin信号传导的新型有效抑制剂。了解更多

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LF3

Catalog No. A16851
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Wnt 抑制剂

LF3通过破坏β-catenin和TCF4之间的相互作用（IC50小于2 uM）是典型Wnt信号传导的特异性抑制剂。了解更多

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KYA1797K

Catalog No. A16353
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Wnt/beta-catenin 抑制剂

KYA1797K是一种高效且选择性的Wnt/β-catenin抑制剂，IC50为0.75 μM（TOPflash分析）。了解更多

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ICG-001

Catalog No. A11039
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Wnt/beta-catenin 抑制剂

ICG-001是Wnt/β-catenin信号传导途径的特异性抑制剂，可抑制β-catenin/环状AMP响应元件结合（CREB）蛋白的转录（IC50 = 3 uM）。了解更多

Product Citations (5)

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- Seonmin Choi, .et al. Indocyanine Green-Loaded PLGA Nanoparticles Conjugated with Hyaluronic Acid Improve Target Specificity in Cervical Cancer Tumors, Yonsei Med J, 2021, Nov;62(11):1042-1051 PMID: 34672138
- Jasper C.Munro, .et al. Cardiac function and feed efficiency: increased right-heart workload in feed inefficient beef cattle, Livest Sci, 2019, 229 (2019) 159-169
- Kim JH, .et al. Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus, Cell Rep, 2019, May 14;27(7):2105-2118.e5 PMID: 31091449
- Yamaoka R, .et al. CD90 expression in human intrahepatic cholangiocarcinoma is associated with lymph node metastasis and poor prognosis, J Surg Oncol, 2018, Sep;118(4):664-674 PMID: 30196535
- Aida Y, .et al. Wnt3a promotes differentiation of human bone marrow-derived mesenchymal stem cells into cementoblast-like cells, In Vitro Cell Dev Biol Anim, 2018, Jun;54(6):468-476 PMID: 29785536
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XAV 939

Catalog No. A10994
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PARP 抑制剂

XAV 939是TNKS抑制剂（TNKS1和TNKS2的IC50值分别为0.011和0.004μM）。了解更多

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- Shizu Aikawa, .et al. Autotaxin-lysophosphatidic acid-LPA 3 signaling at the embryo-epithelial boundary controls decidualization pathways, EMBO J, 2017, Jul 14; 36(14): 2146-2160 PMID: 28588064
- Mikaël M. Martino, .et al. Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration, Nat Commun, 2016, 7: 11051 PMID: 27001940
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KY02111

Catalog No. A12362
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Wnt 抑制剂

KY02111是一种有效的选择性wnt信号通路抑制剂，通过基于细胞的筛选发现，当用于分化的第二阶段时，它促进hesc/ipscs向心肌细胞的分化。是一种有效的选择性wnt信号通路抑制剂，通过基于细胞的筛选发现，当用于分化的第二阶段时，它促进hesc/ipscs向心肌细胞的分化。了解更多

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LGK-974

Catalog No. A12816
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PORCN 抑制剂

LGK974是高效，选择性和口服生物利用性的豪猪抑制剂（Wnt信号拮抗剂），在Wnt信号报告基因测定和豪猪结合测定中IC50 <1 nM。了解更多

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- A-Ri Cho, .et al. RNF43 R117fs mutant positively regulates Wnt/β-catenin signaling by failing to internalize FZD expressed on the cell surface, Sci Rep, 2022, Apr 29;12(1):7013 PMID: 35487932
- Yang JM, .et al. LGK974, a PORCUPINE inhibitor, mitigates cytotoxicity in an in vitro model of Parkinson's disease by interfering with the WNT/β-CATENIN pathway, Toxicology, 2018, Dec 1;410:65-72 PMID: 30205152
- E Lemieux, .et al. Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer, Oncogene, 2015, Sep 17; 34(38): 4914-4927 PMID: 25500543
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IWR-1-endo

Catalog No. A12737
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Wnt 抑制剂

IWR-1-endo是Wnt应答的有效抑制剂，可阻断基于细胞的Wnt /β-catenin途径报道分子应答，IC50值为180 nM。 Wnt蛋白与细胞表面的受体结合，启动信号级联反应，从而导致β-catenin激活基因转录。了解更多

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- Charles A.Herring, .et al. Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution, Cell, 2022, Oct 27;S0092-8674(22)01258-2 PMID: 36318921
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IWP-2

Catalog No. A12707
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Wnt 抑制剂

IWP-2是Porcn功能的灭活剂和Wnt生成的抑制剂，无细胞试验中IC50为27 nM,并阻止β-catenin的积累。Wnt/b-catenin途径维持使干细胞保持多能性的转录程序。了解更多

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Wnt-C59

Catalog No. A12951
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PORCN/Wnt 抑制剂

Wnt-C59是一种非常有效且高度选择性的Wnt信号拮抗剂，在Wnt信号报告基因分析中的IC50?74 pM。了解更多

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- Laksitorini MD, .et al. Modulation of Wnt/β-catenin signaling promotes blood-brain barrier phenotype in cultured brain endothelial cells, Sci Rep, 2019, Dec 23;9(1):19718 PMID: 31873116
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IWP-L6

Catalog No. A13978
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PORCN 抑制剂

IWP-L6是豪猪(Porcn) (一种膜结合的O-酰基转移酶（MBOAT)，EC50 = 0.5 nM) 的有效抑制剂。了解更多

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JW74

Catalog No. A16219
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Wnt 抑制剂

JW74是典型的Wnt信号传导的有效和特异性抑制剂。JW74显示ST-Luc分析中规范Wnt信号的减少，IC50值为790 nM。了解更多

Product Citations (1)

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- Yang JM, .et al. LGK974, a PORCUPINE inhibitor, mitigates cytotoxicity in an in vitro model of Parkinson's disease by interfering with the WNT/β-CATENIN pathway, Toxicology, 2018, Dec 1;410:65-72 PMID: 30205152
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Hexachlorophene

Catalog No. A16217
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Wnt/beta-catenin 抑制剂

Hexachlorophene是一种有效的KCNQ1/KCNE1钾通道激活剂，EC50为4.61±1.29 uM。也是Wnt/β-catenin信号的抑制剂。了解更多

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CCT251545

Catalog No. A16216
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Wnt 抑制剂

CCT251545是口服有效的WNT信号抑制剂，IC50值为5 nM。了解更多

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IWP-3

Catalog No. A13192
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Wnt 抑制剂

IWP-3是Wnt产生的抑制剂。在体外阻断Wnt途径的活性（IC 50 = 40 nM）。IWP-3使豪猪（Porcn）失活，豪猪（Porcn）是一种膜结合的O-酰基转移酶，负责棕榈酸化Wnt蛋白，这对于其信号传导能力和分泌至关重要。通过阻断Wnt信号传导，IWP-3已被用于促进人类胚胎干细胞（EC??= 1.2μM）产生心肌细胞。了解更多

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IQ-1

Catalog No. A16064
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Wnt/beta-catenin 抑制剂

IQ-1是可透过细胞的四氢异喹啉亚基化合物，可调节Wnt/β-catenin信号传导。了解更多

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ETC-159

Catalog No. A15840
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Wnt 抑制剂

ETC-159是Wnt分泌的有效和特异性抑制剂。ETC-159以剂量依赖性方式抑制β-catenin报告基因的活性，IC50为2.9 nM。了解更多

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