Wortmannin

Name: Wortmannin
SKU: A11161

目录号: A11161

PI3K 抑制剂

Product Citations (1)

Wortmannin Chemical Structure

CAS NO. 19545-26-7

Wortmannin是一种有效的，选择性的，可透过细胞的且不可逆的磷脂酰肌醇3-激酶（PI 3-激酶）（IC50 = 2-4 nM）抑制剂，它也有效抑制polo-like激酶1（PLK1）（IC50 = 5.8 nM）。

库存：现货

规格	价格	数量
5 mg	￥ 560.00
10 mg	￥ 770.00
25 mg	￥ 1,680.00
50 mg	￥ 2,660.00
10mM * 1mL in DMSO	￥ 595.00

或

添加到收藏

产品仅用于科学研究，不针对患者销售，望谅解.

产品详情

生物活性

靶点信息

PI3K (Cell-free assay)	DNA-PK [12](Cell-free assay)	ATM [12](Cell-free assay)	MLCK (Cell-free assay)	ATR [12](Cell-free assay)
3 nM	16 nM	150 nM	170 nM	1.8 μM

溶解度 *

In vitro (25°C)	DMSO	73 mg/mL (170.38 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+40% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.34 mL	116.71 mL	233.41 mL
0.5 mM	4.67 mL	23.34 mL	46.68 mL
1 mM	2.33 mL	11.67 mL	23.34 mL
5 mM	0.47 mL	2.33 mL	4.67 mL

*The above data is based on the productmolecular weight 428.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11161
作用机制	Inhibitor (抑制剂)
M. Wt	428.43
Formula	C23H24O8
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	19545-26-7
Synonyms	SL-2052
SMILES	CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@]4([C@H](OC(=O)C5=COC(=C54)C3=O)COC)C)C