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WZ3146是EGFR受体激酶突变体的抑制剂，该突变体在活性位点网守残基（T790M）中带有突变，并且对野生型EGFR激酶的效力要低得多。
靶点信息
| EGFR (L858R) | EGFR (E746_A750) | EGFR (L858R/T790M) | EGFR (E746_A750/T790M) | |
| 2 nM | 2 nM | 5 nM | 14 nM |
| In vitro | DMSO | 83 mg/mL (178.51 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.51 mL | 107.53 mL | 215.05 mL |
| 0.5 mM | 4.3 mL | 21.51 mL | 43.01 mL |
| 1 mM | 2.15 mL | 10.75 mL | 21.51 mL |
| 5 mM | 0.43 mL | 2.15 mL | 4.3 mL |
*The above data is based on the productmolecular weight 465.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10990 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 465.0 |
| Formula | C24H25ClN6O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1214265-56-1 |
| Synonyms | WZ-3146 |
| SMILES | CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl |
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