微信关注
China
Total item
Cart Subtotal
￥ 0.00 产品详情
WZ4002是一种新型的，突变选择性EGFR抑制剂，作用于EGFR(L858R)/(T790M)，在BaF3细胞系中IC50为2 nM/8 nM；对ERBB2磷酸化(T798I)没有抑制作用。
靶点信息
| EGFR (L858R) (BaF3 cells) | EGFR (L858R/T790M) (BaF3 cells) | |||
| 2 nM | 8 nM |
| In vitro (25°C) | DMSO | 12 mg/mL (24.28 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.2 mL | 101.01 mL | 202.02 mL |
| 0.5 mM | 4.04 mL | 20.2 mL | 40.4 mL |
| 1 mM | 2.02 mL | 10.1 mL | 20.2 mL |
| 5 mM | 0.4 mL | 2.02 mL | 4.04 mL |
*The above data is based on the productmolecular weight 495.0. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10991 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 495.0 |
| Formula | C25H27ClN6O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1213269-23-8 |
| SMILES | CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl)OC |
产品标签
Product Questions
Product Questions
No Questions
您还可能对下列产品感兴趣
AG-1478 (Tyrphostin AG-1478)
AG-1478 (Tyrphostin AG-1478)是EGFR激酶的抑制剂，IC50值为3 nM。
Boceprevir (SCH-503034)
Boceprevir (SCH-503034)是一种蛋白酶抑制剂，可用于治疗C型肝炎基因型1。
AZD-9291 (Osimertinib)
AZD-9291 (Osimertinib)是第三代EGFR抑制剂，在临床前研究中显示出希望，并为已对现有EGFR抑制剂产生耐药性的…
Gefitinib (Iressa)
Gefitinib (Iressa)是一种EGFR抑制剂，可阻断靶细胞中表皮生长因子受体(EGFR)的信号传导。
Keywords:购买 WZ4002 | WZ4002 供应商 | 订购 WZ4002 | WZ4002 价格 | WZ4002 生产商 | 订单 WZ4002 | WZ4002 代理商 | 购买 1213269-23-8| 1213269-23-8 供应商 | 订购 1213269-23-8 | 1213269-23-8 价格 | 1213269-23-8 生产商 | 订单 1213269-23-8 | 1213269-23-8 代理商|buy WZ4002 | WZ4002 Supplier | purchase WZ4002 | WZ4002 cost | WZ4002 manufacturer | order WZ4002 | WZ4002 distributor | buy 1213269-23-8| 1213269-23-8 Supplier | purchase 1213269-23-8 | 1213269-23-8 cost | 1213269-23-8 manufacturer | order 1213269-23-8 | 1213269-23-8 distributor
联系我们
United StatesAdooq Bioscience
Toll Free: (866) 930-6790
Fax: +1-323-606-8156
Email: sales@adooq.com
Not your Region? View all Distributors
ADOOQ 产品质量保证
We promise all products to perform as described.