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WZ8040是一种新型的EGFR抑制剂，可抑制含有EGFR-T790M的细胞系的生长并抑制EGFR磷酸化。
靶点信息
| EGFR (T790M) | ||||
| In vitro | DMSO | 86 mg/mL (178.79 mM) | |
| Water | Insoluble | ||
| Ethanol | 3 mg/mL (6.23 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.79 mL | 103.95 mL | 207.9 mL |
| 0.5 mM | 4.16 mL | 20.79 mL | 41.58 mL |
| 1 mM | 2.08 mL | 10.4 mL | 20.79 mL |
| 5 mM | 0.42 mL | 2.08 mL | 4.16 mL |
*The above data is based on the productmolecular weight 481.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10992 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 481.0 |
| Formula | C24H25ClN6OS |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1214265-57-2 |
| Synonyms | WZ-8040 |
| SMILES | CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)SC4=CC=CC(=C4)NC(=O)C=C)Cl |
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