XEN445

Name: XEN445
SKU: A13150

目录号: A13150

Endothelial lipase(EL) 抑制剂

XEN445 Chemical Structure

CAS NO. 1515856-92-4

XEN445是内皮脂肪酶(EL)抑制剂，IC50为0.237 uM，具有很好的ADME和PK活性，能提高小鼠血浆中高密度脂蛋白胆固醇浓度。

库存：现货

规格	价格	数量
2 mg	￥ 280.00
5 mg	￥ 490.00
10 mg	￥ 910.00
10mM * 1mL in DMSO	￥ 770.00

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生物活性

XEN445是内皮脂肪酶(EL)抑制剂，IC50为0.237 uM，具有很好的ADME和PK活性，能提高小鼠血浆中高密度脂蛋白胆固醇浓度。

靶点信息

溶解度 *

Targets

endothelial lipase
0.237 μM

In vitro	DMSO	79 mg/mL (215.65 mM)
	Water	Insoluble
	Ethanol	Warmed: 34 mg/mL (92.81 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.3 mL	136.49 mL	272.98 mL
0.5 mM	5.46 mL	27.3 mL	54.6 mL
1 mM	2.73 mL	13.65 mL	27.3 mL
5 mM	0.55 mL	2.73 mL	5.46 mL

*The above data is based on the productmolecular weight 366.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A13150
作用机制	Inhibitor (抑制剂)
M. Wt	366.33
Formula	C18H17F3N2O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1515856-92-4
Synonyms	XEN-445, XEN 445
SMILES	C1CN(CC1OCC2=CC=CC=N2)C3=C(C=C(C=C3)C(F)(F)F)C(=O)O