XL-147 (Pilaralisib)

Name: XL-147 (Pilaralisib)
SKU: A15283

目录号: A15283

PI3K 抑制剂

XL-147 (Pilaralisib) Chemical Structure

CAS NO. 934526-89-3

XL-147 (Pilaralisib)是I类PI3K脂质激酶家族有效的生物利用抑制剂。

库存：现货

规格	价格	数量
5 mg	￥ 420.00
10 mg	￥ 700.00
25 mg	￥ 1,400.00

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生物活性

XL-147 (Pilaralisib)是I类PI3K脂质激酶家族有效的生物利用抑制剂。

靶点信息

PI3Kγ	PI3Kβ	PI3Kδ	PI3Kα
23 nM	36 nM	36 nM	39 nM

溶解度 *

In vitro (25°C)	DMSO	Warmed: 92 mg/mL (170.04 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	10 mM HCl in sterile water	0.4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.48 mL	92.42 mL	184.84 mL
0.5 mM	3.7 mL	18.48 mL	36.97 mL
1 mM	1.85 mL	9.24 mL	18.48 mL
5 mM	0.37 mL	1.85 mL	3.7 mL

*The above data is based on the productmolecular weight 541.02. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A15283
作用机制	Inhibitor (抑制剂)
M. Wt	541.02
Formula	C25H25ClN6O4S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	934526-89-3
Synonyms	SAR245408, XL 147, XL147, SAR-245408, SAR 245408, pilaralisib
SMILES	CC(C)(C(=O)NC1=CC(=CC=C1)S(=O)(=O)NC2=NC3=CC=CC=C3N=C2NC4=C(C=CC(=C4)OC)Cl)N