17-AAG (KOS953)

Name: 17-AAG (KOS953)
SKU: A10010

目录号: A10010

HSP90 抑制剂

Product Citations (1)

17-AAG (KOS953) Chemical Structure

CAS NO. 75747-14-7

17-AAG (KOS953)是一种有效的HSP90抑制剂，无细胞试验中IC50为5 nM，作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。

库存：现货

规格	价格	数量
10 mg	￥ 420.00
50 mg	￥ 1,120.00
100 mg	￥ 1,750.00
200 mg	￥ 2,450.00
10mM * 1mL in DMSO	￥ 574.00

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生物活性

17-AAG (KOS953)是一种有效的HSP90抑制剂，无细胞试验中IC50为5 nM，作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。

靶点信息

HSP90 (Cell-free assay)
5 nM

溶解度 *

In vitro (25°C)	DMSO	97 mg/mL (165.61 mM)
	Water	Insoluble
	Ethanol	5 mg/mL
In vivo	5%DMSO+corn oil	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.07 mL	85.37 mL	170.74 mL
0.5 mM	3.41 mL	17.07 mL	34.15 mL
1 mM	1.71 mL	8.54 mL	17.07 mL
5 mM	0.34 mL	1.71 mL	3.41 mL

*The above data is based on the productmolecular weight 585.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10010
作用机制	Inhibitor (抑制剂)
M. Wt	585.7
Formula	C31H43N3O8
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	75747-14-7
Synonyms	Tanespimycin, NSC330507, CP 127374, KOS-953, KOS 953
SMILES	CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC