17-DMAG HCl (Alvespimycin)

Name: 17-DMAG HCl (Alvespimycin)
SKU: A10011
Price: 175 CNY
Rating: 5 (3 reviews)

目录号: A10011

Hsp90 抑制剂

3 篇发表文献

17-DMAG 是 17-AAG 和 geldanamycin 的水溶性类似物，它结合 Hsp90 的 ATP 结合位点 并抑制其伴侣蛋白活性。显示出比 17-AAG 更强的抗肿瘤活性。

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Grouped product items
规格	价格	库存
5mg	¥175.00	现货
10mg	¥315.00	现货
25mg	¥630.00	现货
50mg	¥1,155.00	现货
100mg	¥1,855.00	现货
200mg	¥2,905.00	现货
*10mM 1mL in DMSO**	¥350.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用17-DMAG HCl (Alvespimycin)发表的3篇文献

Majid Momeny, .et al. , EMBO Mol Med, 2024, Jun 17 PMID: 38886591

Yool Lee, .et al. , Sci Adv, 2021, 7

Naoki Shiraishi, .et al. , Oncol Rep, 2020, 448-458 PMID: 33416122

生物活性

Discription

17-DMAG is a water-soluble analog of 17-AAG and geldanamycin that binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG.

Targets

Target	Value

产品信息

目录号	A10011
分子式	C32H48N4O8.HCl
分子量	653.2
CAS号	467214-21-7
SMILES	CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC.Cl
其他名称	NSC 707545
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	127 mg/mL (194.42 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.31 mL	76.55 mL	153.09 mL
0.5 mM	3.06 mL	15.31 mL	30.62 mL
1 mM	1.53 mL	7.65 mL	15.31 mL
5 mM	0.31 mL	1.53 mL	3.06 mL

Useful Calculator

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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