2-D08
目录号: A16852
SUMO 抑制剂
2-D08 是一种细胞渗透性的，机制独特的蛋白质 sumoylation 抑制剂。它还抑制 Axl、IRAK4、ROS1、MLK4、GSK3β、RET、KDR 和 PI3Kα，在生化实验中的 IC50 值分别为 0.49、3.9、5.3、9.8、11、11、17 和 35 nM。
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生物活性
| Discription | 2-D08 is a cell permeable, mechanistically unique inhibitor of protein sumoylation. It is also inhibits Axl, IRAK4, ROS1, MLK4, GSK3β, RET, KDR and PI3Kα with IC50 values of 0.49, 3.9, 5.3, 9.8, 11, 11, 17 and 35 nM respectively in biochemical assays. |
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产品信息
| 目录号 | A16852 |
|---|---|
| 分子式 | C15H10O5 |
| 分子量 | 270.24 |
| CAS号 | 144707-18-6 |
| SMILES | O=C1C=C(C2=CC=C(O)C(O)=C2O)OC3=CC=CC=C13 |
| 其他名称 | 2D08 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 46 mg/mL (170.22 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 37 mL | 185.02 mL | 370.04 mL |
| 0.5 mM | 7.4 mL | 37 mL | 74.01 mL |
| 1 mM | 3.7 mL | 18.5 mL | 37 mL |
| 5 mM | 0.74 mL | 3.7 mL | 7.4 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 144707-18-6 | 144707-18-6 供应商 | 144707-18-6 花费 | 144707-18-6 生产商 | 订购 144707-18-6 | 144707-18-6 代理商