Signaling Pathway
重要通知：仅供研究使用。我们不向患者销售。
| Discription | 3-deazaneplanocin A, also known as DZNep, is a well-known histone methyltransferase inhibitor, which disrupts polycomb-repressive complex 2 (PRC2), and induces apoptosis, while inhibiting proliferation and metastasis, in cancer cells, including acute myeloid leukemia, breast cancer and glioblastoma. |
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| Targets |
| 目录号 | A13947 |
|---|---|
| 分子式 | C12H15ClN4O3 |
| 分子量 | 298.73 |
| CAS号 | 120964-45-6 |
| SMILES | C1=CN=C(C2=C1N(C=N2)[C@@H]3C=C([C@H]([C@H]3O)O)CO)N.Cl |
| 其他名称 | DZNep, NSC 617989 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
| In vitro (25°C) | DMSO | 49 mg/mL (164.03 mM) | |
| Water | 49 mg/mL (164.03 mM) | ||
| Ethanol | Insoluble | ||
| In vivo | Saline | 28 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 33.48 mL | 167.38 mL | 334.75 mL |
| 0.5 mM | 6.7 mL | 33.48 mL | 66.95 mL |
| 1 mM | 3.35 mL | 16.74 mL | 33.48 mL |
| 5 mM | 0.67 mL | 3.35 mL | 6.7 mL |
