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5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.8 mL | 124.02 mL | 248.03 mL |
| 0.5 mM | 4.96 mL | 24.8 mL | 49.61 mL |
| 1 mM | 2.48 mL | 12.4 mL | 24.8 mL |
| 5 mM | 0.5 mL | 2.48 mL | 4.96 mL |
*The above data is based on the productmolecular weight 403.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A19479 |
|---|---|
| M. Wt | 403.17 |
| Formula | C16H10IN3O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 331467-03-9 |
| SMILES | O/N=C(C1=CC=CC=C1N2)/C2=C3C(NC4=C/3C=C(I)C=C4)=O |
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