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活性化合物
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Signaling Pathway
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Epigenetics | 表观遗传学
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- Apoptosis | 凋亡
- PI3K/Akt/mTOR 信号通路
- Protein Tyrosine Kinases | 蛋白酪氨酸激酶
- Angiogenesis | 血管生成
- MAPK 信号通路
- JAK/Stat 信号通路
- Metabolism | 代谢
- Cell Cycle | 细胞周期
- DNA Damage | DNA 损伤
- Cytoskeleton | 细胞骨架
- Autophagy | 自噬
- Immunology & Inflammation | 免疫和炎症
- GPCR/G Protein | G蛋白偶联受体/G 蛋白
- NF-kB/IkB 信号通路
- TGF-β/Smad 信号通路
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Epigenetics | 表观遗传学
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CCK
Cholecystokinin receptors (CCKRs) are a class of G-protein coupled receptors that respond to the peptide hormone cholecystokinin (CCK). CCK is predominantly found in the gastrointestinal tract and the central nervous system. There are two primary subtypes of cholecystokinin receptors: CCK-A (CCK1) receptor, mainly located in the pancreas, gallbladder, stomach, and certain areas of the brain, and CCK-B (CCK2) receptor, found predominantly in the brain and the stomach lining.
The primary function of CCKRs is to mediate the physiological actions of CCK. In the digestive system, CCK is involved in stimulating the digestion of fats and protein. It achieves this by inducing the secretion of digestive enzymes from the pancreas and bile from the gallbladder. Moreover, CCK plays a crucial role in regulating appetite by promoting satiety, making it a point of interest in obesity research.
In the central nervous system, CCK is involved in various functions, including anxiety, pain, and neuroendocrine control. CCK and its receptors are also implicated in psychiatric disorders like anxiety and panic attacks.
CCKRs are also significant in the medical field as potential targets for therapeutic intervention. For instance, CCK-B antagonists are being explored for their potential in treating anxiety disorders and gastrointestinal issues.
Overall, cholecystokinin receptors are integral to various physiological processes, from digestion to brain function, highlighting their importance in both understanding bodily functions and developing medical treatments.
