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AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.61 mL | 113.04 mL | 226.08 mL |
| 0.5 mM | 4.52 mL | 22.61 mL | 45.22 mL |
| 1 mM | 2.26 mL | 11.3 mL | 22.61 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.52 mL |
*The above data is based on the productmolecular weight 442.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A19085 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 442.32 |
| Formula | C21H13Cl2N3O2S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2247919-28-2 |
| Synonyms | AAPK 25, AAPK25 |
| SMILES | ClC1=CC(C(NC2=CC=C(C=C(C(NC3=NC=CS3)=O)C=C4)C4=C2)=O)=CC=C1Cl |
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