Bcr-Abl

Inhibitory Selectivity

Catalog No.	Inhibitor Name	Bcr-Abl	Abl	Other
A10290	Dasatinib	****	****	Src,c-Kit (D816V),c-Kit (wt)
A10468	Imatinib Mesylate		*	c-Kit,PDGFR
A10108	Saracatinib		**	c-Src,LCK,EGFR (L861Q)
A10080	Ponatinib	****	****	PDGFRα,VEGFR2,FGFR1
A10644	Nilotinib	**
A10715	Danusertib	**	**	Aurora A,TrkA,RET
A10095	AT9283		***	JAK3,JAK2,Aurora B
A10988	Degrasyn	*		DUB
A10119	Bafetinib	***	***	Lyn
A10508	KW-2449	**	***	FLT3 (D835Y),FLT3,FGFR1
A10661	NVP-BHG712		*	EphB4,C-Raf,c-Src
A11200	Rebastinib		***	FLT3,KDR,Tie-2
A15849	GZD824 Dimesylate	****	****
A11439	GNF-2	*
A15887	GNF-7	***	*
A13029	Radotinib	**
A16320	Dasatinib Monohydrate	****	****	Src,c-Kit (D816V),c-Kit (wt)
A13237	GNF-5	*
A13120	PD173955	***		Src
A11379	DPH
A13530	Flumatinib mesylate		****	PDGFRβ, c-Kit

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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Danusertib (PHA-739358)

Catalog No. A10715
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Aurora 抑制剂

Danusertib (PHA-739358)是Aurora A/B/C的Aurora激酶抑制剂，在无细胞分析中的IC50为13 nM/79nM/61 nM，对Abl，TrkA，c-RET和FGFR1以及更低的浓度具有中等效力对Lck，VEGFR2/3，c-Kit，CDK2等有效。了解更多

Product Citations (1)

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- Samuel Q. Li, etc. Targeting Wild-Type and Mutationally Activated FGFR4 in Rhabdomyosarcoma with the Inhibitor Ponatinib (AP24534). PLoS One. 2013; 8(10): e76551.
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AT9283

Catalog No. A10095
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Aurora/JAK 抑制剂

AT9283抑制极光激酶A和B，并靶向与骨髓细胞增殖相关的其他酪氨酸和丝氨酸/苏氨酸激酶。了解更多

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- Tomoya Takeda, .et al. AT9283 exhibits antiproliferative effect on tyrosine kinase inhibitor-sensitive and -resistant chronic myeloid leukemia cells by inhibition of Aurora A and Aurora B, Oncol Rep, 2020, August 18