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Acadesine (Aicar,NSC 105823)是肝细胞和脂肪细胞中AMPK的选择性激活剂。
靶点信息
AMPK (Cell-free assay) | AMPKK (Cell-free assay) | |||
In vitro (25°C) | DMSO | 44 mg/mL (170.38 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 2% DMSO+40% PEG 300+2% Tween 80+ddH2O | 5 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 38.73 mL | 193.65 mL | 387.3 mL |
0.5 mM | 7.75 mL | 38.73 mL | 77.46 mL |
1 mM | 3.87 mL | 19.36 mL | 38.73 mL |
5 mM | 0.77 mL | 3.87 mL | 7.75 mL |
*The above data is based on the productmolecular weight 258.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
目录号 | A10028 |
---|---|
作用机制 | Activator (激活剂) |
M. Wt | 258.2 |
Formula | C9H14N4O5 |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. |
CAS No. | 2627-69-2 |
Synonyms | AICAR, AICA-riboside, NSC-105823, NSC105823 |
SMILES | C1=NC(=C(N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N)C(=O)N |
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