Acalisib (GS-9820)
目录号: A14441
PI3Kδ Inhibitor
Acalisib 是一种抑制剂,针对的是 110 kDa 催化亚单位的 IA 类磷脂酰肌醇-3激酶(PI3K)的 β 和 δ 亚型,具有潜在的免疫调节和抗肿瘤活性。
Discription | Acalisib is an inhibitor of the beta and delta isoforms of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities. | ||
---|---|---|---|
Targets |
|
目录号 | A14441 |
---|---|
分子式 | C21H16FN7O |
分子量 | 401.4 |
CAS号 | 870281-34-8 |
SMILES | CC(C1=NC2=C(C=C(C=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5 |
其他名称 | GS-9820 |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
In vitro | DMSO | 76 mg/mL (189.34 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 24.91 mL | 124.56 mL | 249.13 mL |
0.5 mM | 4.98 mL | 24.91 mL | 49.83 mL |
1 mM | 2.49 mL | 12.46 mL | 24.91 mL |
5 mM | 0.5 mL | 2.49 mL | 4.98 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2