Aclacinomycin A

Name: Aclacinomycin A
SKU: A14910
Price: 1260 CNY
Rating: 5 (288 reviews)

目录号: A14910

20S proteasome 抑制剂

Aclarubicin A，一种蒽环类药物，是20S蛋白酶体胰蛋白酶样活性的特异性抑制剂。

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规格	价格	库存
1mg	¥1,260.00	现货
5mg	¥3,220.00	现货
10mg	¥5,740.00	现货
25mg	¥11,200.00	现货
50mg	¥19,600.00	现货
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Data Sheet

SDS

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生物活性

Discription

Aclarubicin A, an anthracycline drug, specific inhibitor of the 20S proteasome chymotrypsin-like activity.

Cell Research

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Cell Line	Type	Value	Description	References
DU-145	IC50	0.129 μM	Cytotoxicity in human DU-145 cells assessed as reduction in cell viability incubated for 2 hrs by Cell-titer-blue assay	[PMID: 33064004]
HCT-116	IC50	0.04 μM	Cytotoxicity in human HCT-116 cells assessed as reduction in cell viability incubated for 2 hrs by Cell-titer-blue assay	[PMID: 33064004]
K562	IC50	0.076 μM	Cytotoxicity in human K562 cells assessed as reduction in cell viability incubated for 2 hrs by Cell-titer-blue assay	[PMID: 33064004]
MEL-JUSO	IC50	0.048 μM	Cytotoxicity in human MEL-JUSO cells assessed as reduction in cell viability incubated for 2 hrs by Cell-titer-blue assay	[PMID: 33064004]
PC-3	IC50	0.101 μM	Cytotoxicity in human PC-3 cells assessed as reduction in cell viability incubated for 2 hrs by Cell-titer-blue assay	[PMID: 33064004]
U-87MG ATCC	IC50	0.137 μM	Cytotoxicity in human U87 cells assessed as reduction in cell viability incubated for 2 hrs by Cell-titer-blue assay	[PMID: 33064004]

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产品信息

目录号	A14910
分子式	C42H53NO15
分子量	811.87
CAS号	57576-44-0
SMILES	CCC1(CC(C2=C(C1C(=O)OC)C=C3C(=C2O)C(=O)C4=C(C3=O)C=CC=C4O)OC5CC(C(C(O5)C)OC6CC(C(C(O6)C)OC7CCC(=O)C(O7)C)O)N(C)C)O
其他名称	Jaclacin, Aclarubicin
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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