ADAMs

The ADAMs (a disintegrin and metalloproteases) family of transmembrane proteins belongs to the zinc protease superfamily. Members of the family have a modular design, characterized by the presence of metalloprotease and integrin receptor-binding activities, and a cytoplasmic domain that in many family members specifies binding sites for various signal transducing proteins. The ADAMs family has been implicated in the control of membrane fusion, cytokine and growth factor shedding, and cell migration, as well as processes such as muscle development, fertilization, and cell fate determination.

Quick View
TMI-1

Catalog No. A17212
Quick View

添加到收藏
TACE/MMP 抑制剂

TMI-1是ADAM17（TACE）和MMP的新型活性双重抑制剂。了解更多

Bulk Inquiry
Quick View
TAPI-1

Catalog No. A14070
Quick View

添加到收藏
TACE/MMP 抑制剂

TAPI-1是一种ADAM17/TACE抑制剂, 其对细胞因子受体有抑制作用。了解更多

Bulk Inquiry
Quick View
TAPI-0

Catalog No. A13724
Quick View

添加到收藏
TACE/MMP 抑制剂

TAPI-0是TACE（IC50 = 50-100 nM）以及其他基质和膜金属蛋白酶的抑制剂。了解更多

Bulk Inquiry
Quick View
TAPI-2

Catalog No. A14009
Quick View

添加到收藏
TACE/MMP 抑制剂

TAPI-2是TACE，ADAM，ACE分泌酶和其他MMP（金属蛋白酶）的抑制剂。TAPI-2阻止DCC7，APP，TNFα，L-选择素，NOTCH，TGFα，IL-6R9，erbB2/HER2和ACE的释放。该抑制剂已用于组织培养。了解更多

Bulk Inquiry
Quick View
GI 254023X

Catalog No. A15322
Quick View

添加到收藏
ADAM10 metalloprotease 抑制剂

GI 254023X是一种选择性的ADAM10金属蛋白酶抑制剂；与ADAM17相比，ADAM10的效能高出100倍以上。了解更多

Bulk Inquiry