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AG-014699 (Rucaparib)

AG-014699 (Rucaparib)

Name: AG-014699 (Rucaparib)
SKU: A10045

目录号: A10045

PARP 抑制剂

Product Citations (1)

AG-014699 (Rucaparib) Chemical Structure

CAS NO. 459868-92-9

AG-014699 (Rucaparib)是一种PARP抑制剂，可抑制聚（ADP-核糖）聚合酶（PARP，后者是DNA修复中的关键酶。无细胞试验中作用于PARP1的Ki为1.4 nM，对其余8个PARP位点也有结合亲和力。

库存：现货

规格	价格	数量
5 mg	￥ 420.00
25 mg	￥ 1,540.00
50 mg	￥ 1,890.00
100 mg	￥ 2,954.00
10mM * 1mL in DMSO	￥ 770.00

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生物活性

靶点信息

PARP (Cell-free assay)
1.4 nM(Ki)

溶解度 *

In vitro (25°C)	DMSO	81 mg/mL (192.23 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.73 mL	118.65 mL	237.3 mL
0.5 mM	4.75 mL	23.73 mL	47.46 mL
1 mM	2.37 mL	11.87 mL	23.73 mL
5 mM	0.47 mL	2.37 mL	4.75 mL

*The above data is based on the productmolecular weight 421.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10045
作用机制	Inhibitor (抑制剂)
M. Wt	421.4
Formula	C19H18FN3O.H3PO4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	459868-92-9
Synonyms	AG014699, PF-01367338,AG-014447 (as free base)
SMILES	CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=CC(=CC(=C34)N2)F.OP(=O)(O)O