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AG-17是人表皮样癌细胞系A431中EGFR激酶的抑制剂，IC50值为460 μM，作用于PDGFR更有效，IC50值为0.5μM。
靶点信息
| PDGFR | EGFR | |||
| 0.5 μM | 460 μM |
| In vitro | DMSO | 51 mg/mL (180.6 mM) | |
| Water | Insoluble | ||
| Ethanol | 51 mg/mL (180.6 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35.41 mL | 177.05 mL | 354.11 mL |
| 0.5 mM | 7.08 mL | 35.41 mL | 70.82 mL |
| 1 mM | 3.54 mL | 17.71 mL | 35.41 mL |
| 5 mM | 0.71 mL | 3.54 mL | 7.08 mL |
*The above data is based on the productmolecular weight 282.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11949 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 282.4 |
| Formula | C18H22N2O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 10537-47-0 |
| Synonyms | NSC 242557, RG-50872, GCP 5126, SF 6847, Tyrphostin AG-17, Malonoben, Tyrphostin 9 |
| SMILES | CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C=C(C#N)C#N |
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