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AGN-242428，也称为VTP-43742，是一种有效的，选择性的和口服活性的RORγ抑制剂，Ki值为<100 nM。用于治疗自身免疫性疾病，包括多发性硬化症和牛皮癣。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.09 mL | 90.47 mL | 180.95 mL |
| 0.5 mM | 3.62 mL | 18.09 mL | 36.19 mL |
| 1 mM | 1.81 mL | 9.05 mL | 18.09 mL |
| 5 mM | 0.36 mL | 1.81 mL | 3.62 mL |
*The above data is based on the productmolecular weight 552.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16935 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 552.65 |
| Formula | C27H35F3N4O3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1802706-04-2 |
| Synonyms | VTP-43742, VTP 43742, VTP43742, AGN242428, AGN 242428 |
| SMILES | CCS(=O)(=O)c1ccc(CNC(=O)c2cnc3[C@H](C(C)C)N(C[C@H]4CC[C@@H](CC4)C(F)(F)F)Cc3c2)nc1 |
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