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Alpelisib hydrochloride (BYL-719 hydrochloride) is a potent, orally active, and selective PI3Kα inhibitor with IC50s of 5 nM, 250 nM, 290 nM and 1200 nM for p110α, p110γ, p110δ, and p110β, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.92 mL | 104.62 mL | 209.24 mL |
| 0.5 mM | 4.18 mL | 20.92 mL | 41.85 mL |
| 1 mM | 2.09 mL | 10.46 mL | 20.92 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.18 mL |
*The above data is based on the productmolecular weight 477.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21794 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 477.93 |
| Formula | C19H23ClF3N5O2S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1584128-91-5 |
| Synonyms | BYL-719 hydrochloride, BYL 719, BYL719 |
| SMILES | CC(N=C(S1)NC(N2CCC[C@H]2C(N)=O)=O)=C1C3=CC(C(C)(C(F)(F)F)C)=NC=C3.Cl |
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